{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:44:25Z","timestamp":1790502265620,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective(s)<\/jats:title><jats:p>This prospective observational cohort study aimed to evaluate whether women with severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection during the first trimester of pregnancy are at higher risk of adverse obstetric and neonatal outcomes compared to negative patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Seromolecular testing for SARS\u2010CoV\u20102 was performed at 12, 16, 21\u2009weeks, and at delivery; the cohort was then subdivided into a first\u2010trimester SARS\u2010CoV\u20102\u2010positive (case) group and a SARS\u2010CoV\u20102\u2010negative (control) group. The primary outcome was a composite adverse obstetric outcome, defined as the presence of either abortion, preterm delivery, preterm prelabor rupture of membranes, preeclampsia, intrauterine growth restriction, stillbirth; and a composite measure of adverse neonatal events, including either 1\u2010 and 5\u2010min Apgar score\u2009\u2264\u20097, neonatal intensive care unit admission and congenital birth defects. Maternal symptoms and antibody titer were secondarily assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 17 of 164 women tested positive for SARS\u2010CoV\u20102 (10.3%) in the first trimester. One SARS\u2010CoV\u20102\u2010positive patient who gave birth at another hospital was excluded. Composite adverse obstetric outcome was observed in 6.2% (1\/16) SARS\u2010CoV\u20102\u2010positive and 10.5% (11\/105) SARS\u2010CoV\u20102\u2010negative women; composite adverse neonatal outcome in 12.5% (2\/16) and 7.6% (8\/105), respectively. In the newborns of women who had developed IgG antibodies, the same antibodies were detected in arterial cord blood and the nasopharyngeal swab tested negative for SARS\u2010CoV\u20102.<\/jats:p><jats:p>No maternal pneumonia or hospital admission due to coronavirus disease\u201019 were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Asymptomatic or mildly symptomatic women during the first trimester of pregnancy did not experience significantly more adverse events than SARS\u2010CoV\u20102\u2010negative women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15105","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:40:22Z","timestamp":1637714422000},"page":"393-401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Obstetric and neonatal outcomes after <scp>SARS\u2010CoV<\/scp>\u20102 infection in the first trimester of pregnancy: A prospective comparative study"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0563-0071","authenticated-orcid":false,"given":"Stefano","family":"Cosma","sequence":"first","affiliation":[{"name":"Gynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7734-4499","authenticated-orcid":false,"given":"Andrea Roberto","family":"Carosso","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Cusato","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Pharmacology and Pharmacogenetics, Amedeo di Savoia Hospital, Department of Medical Sciences University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulvio","family":"Borella","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Bertero","sequence":"additional","affiliation":[{"name":"Pathology Unit, Department of Medical Sciences, City of Health and Science University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marialuisa","family":"Bovetti","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Bevilacqua","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Mengozzi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine City of Health and Science  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaela","family":"Mazzone","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine City of Health and Science  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Ghisetti","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Virology Amedeo di Savoia Hospital, ASL  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Di Perri","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Amedeo di Savoia Hospital, Department of Medical Sciences University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Benedetto","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Coronavirus Disease (COVID\u201019)\u2014events as they happen. 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