{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T07:23:10Z","timestamp":1778570590415,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T00:00:00Z","timestamp":1638057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Fetal growth restriction (FGR) has significant consequences on cardiac functions. This study aims to evaluate cardiac functional parameters in late\u2010onset (FGR) fetuses and compare those appropriate for gestational age (AGA) fetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Fifty\u2010six singleton pregnancies were involved in this prospective case\u2013control study. Delphi consensus was used to define late\u2010onset FGR. We compared the E\/A ratio, left myocardial performance index (MPI) and tricuspid annular plane systolic excursion (TAPSE) in late\u2010onset FGR cases and gestational age\u2010matched AGA fetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010eight late\u2010onset FGR and 28 AGA fetuses were enrolled. The mean gestational age in the late\u2010onset FGR group was 34.1\u2009\u00b1\u20092.3\u2009weeks and 34.4\u2009\u00b1\u20092.1 in controls. The E\/A ratio was 0.88\u2009\u00b1\u20090.09 in AGA fetuses, 0.79\u2009\u00b1\u20090.11 in the late\u2010onset FGR group, and significantly lower in late\u2010onset FGR fetuses (<jats:italic>p<\/jats:italic>: 0.012). Left MPI was 0.51\u2009\u00b1\u20090.09 in AGA and 0.62\u2009\u00b1\u20090.11 in the late\u2010onset FGR group. Left MPI was markedly higher in late\u2010onset FGR fetuses (<jats:italic>p<\/jats:italic>: 0.024). TAPSE was 7.4\u2009\u00b1\u20092.9\u2009mm in controls and 5.2\u2009\u00b1\u20091.8 in the late\u2010onset FGR group, and it was significantly shorter in the late\u2010onset FGR fetuses (<jats:italic>p<\/jats:italic>: 0.016).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Late\u2010onset FGR is associated with cardiac remodeling and dysfunction. Fetal echocardiography may be beneficial to detect those subtle cardiac changes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15114","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T05:10:20Z","timestamp":1638162620000},"page":"373-378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Fetal cardiac alterations in the late\u2010onset growth\u2010restricted fetuses: A prospective case\u2013control study"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5514-0233","authenticated-orcid":false,"given":"Gurcan","family":"Turkyilmaz","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maternal\u2010Fetal Medicine Unit Van Education and Research Hospital  Van 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