{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T08:51:08Z","timestamp":1776156668629,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:00:00Z","timestamp":1645574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrine disorders in females of reproductive age, with a prevalence of 20%\u201333% in the general population. Interleukin (IL)\u201034 is a recently explored proinflammatory cytokine and is an important modulator in different disease types. However, the function of IL\u201034 in PCOS has yet to be investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this study was to determine the IL\u201034 serum level in women with PCOS and to compare it to that of a relatively healthy control group. Focusing on its relationship with IL\u20106, TNF\u2010\u03b1, and IL\u20101\u03b2 and homeostatic model assessment for insulin resistance (HOMA\u2010IR), triglyceride, and low\u2010density lipoprotein cholesterol (LDL\u2010C).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In this study, blood samples were obtained from 100 women with PCOS and 100 healthy control women for the purpose of estimating their serum levels of IL\u201034, IL\u20106, TNF\u2010\u03b1, and IL\u20101\u03b2 using the enzyme\u2010linked immunosorbent assay technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum levels of IL\u201034, IL\u20106, TNF\u2010\u03b1, and IL\u20101\u03b2 were all higher in PCOS women than in healthy controls, and the difference was highly statistically significant. Serum IL\u201034 concentration was positively correlated with IL\u20106, TNF\u2010\u03b1, and IL\u20101\u03b2 concentration. Additionally, serum concentrations of IL\u201034 were positively correlated with HOMA\u2010IR, triglyceride, and LDL\u2010C.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>When compared to normal women, IL\u201034, IL\u20106, TNF\u2010\u03b1, and IL\u20101\u03b2 levels were highly statistically significant in PCOS, and these high levels were associated with other cytokines (IL\u20106, TNF\u2010\u03b1, and IL\u20101\u03b2), HOMA\u2010IR, triglyceride, and LDL\u2010C.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15141","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T23:23:06Z","timestamp":1645658586000},"page":"973-979","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp>IL<\/scp>\u201034 was high in serum of women with polycystic ovary syndrome and may function as potential diagnostic biomarker and therapeutic 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