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ART practice in Japan is unique with various types of ovarian stimulation protocols, which may contribute to lower pregnancy rates compared to other countries. This review aims to clarify optimal individualized ovarian stimulation for improving the pregnancy rate per one oocyte retrieval cycle in Japan. We performed a literature review to describe ovarian stimulation, classification of infertile women depending on ovarian reserve and response, and Japanese ART data and discussed optimal conventional and mild ovarian stimulation protocols in Japan. According to Japanese ART registry data, the live birth rate of 30\u201335\u2010year\u2010old women was 32%\u201337% per ET cycle; therefore, four to five embryos are calculatedly needed when aiming a cumulative live birth rate of \u226580%. Mild stimulation aimed at collecting 5\u201310 oocytes can be alternative choice as an optimal ovarian stimulation protocol in young women. In 40\u2010year\u2010old women, the live birth rate is 18.8%, resulting in eight or more embryos as necessary. Conventional stimulation must be required in women with advanced age. In poor responders, however, mild stimulation may be sufficient for maximumly extracting their ovarian function. In Japan, mild ovarian stimulation can be selected in patients with a good prognosis and poor responders; however, conventional ovarian stimulation is necessary for women in advanced age.<\/jats:p>","DOI":"10.1111\/jog.15150","type":"journal-article","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T00:24:54Z","timestamp":1642119894000},"page":"521-532","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Optimal individualization of patient\u2010oriented ovarian stimulation in Japanese assisted reproductive technology clinics, a review for unique setting with advanced\u2010age patients"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2759-9159","authenticated-orcid":false,"given":"Keiji","family":"Kuroda","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine and Implantation Research Sugiyama Clinic Shinjuku  Tokyo Japan"},{"name":"Department of 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