{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:40:00Z","timestamp":1768524000317,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T00:00:00Z","timestamp":1645056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Reliable aneuploidy risk estimation in first trimester is prominently interconnected with accurate assessment of maternal serum biomarkers. Some maternal factors like insulin\u2010dependent diabetes, weight, and rhesus status are known to alter levels of these biomarkers. Adjustment of biomarker values for specific factor is crucial to avoid excessive invasive procedures or missed diagnoses. We aimed to investigate the effects of noncavity distorting intramural uterine fibroids on first trimester aneuploidy screening test maternal serum biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pregnant women who underwent first trimester aneuploidy screening test in a single tertiary center between 2011 and 2020 were retrospectively assessed. One hundred ninety\u2010eight women were found to have at least one noncavity distorting intramural uterine leiomyoma (Figo type 3\u20136) of at least 2\u00a0cm diameter and remaining women were assigned as controls. First trimester aneuploidy screening test parameters were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pregnancy associated plasma protein\u2010A (PAPP\u2010A) MoMs were found significantly lower in leiomyoma group in comparison to control group (1.19\u2009\u00b1\u20090.60 MoM vs. 1.40\u2009\u00b1\u20090.73 MoM, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002). PAPP\u2010A MoMs in women with leiomyomas larger than 5.5\u00a0cm were significantly lower in comparison to both control group and women with \u22645.5\u00a0cm leiomyomas (0.82\u2009\u00b1\u20090.376 vs. 1.40\u2009\u00b1\u20090.73, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; 0.82\u2009\u00b1\u20090.376 vs. 1.33\u2009\u00b1\u20090.61 <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, respectively). PAPP\u2010A MoM and size of leiomyoma were found inversely correlated when fibroid size exceeds 5.5\u00a0cm (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.467, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Noncavity distorting intramural uterine leiomyomas &gt;5.5\u00a0cm are associated with low first trimester PAPP\u2010A MoMs (&lt;0.5). PAPP\u2010A concentrations are inversely correlated with fibroid size in women with &gt;5.5\u00a0cm intramural uterine leiomyomas. Fibroids \u22645.5\u00a0cm are not associated with alterations in first trimester aneuploidy screening test parameters.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15188","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T10:00:27Z","timestamp":1645092027000},"page":"1091-1098","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Low first trimester maternal serum <scp>PAPP\u2010A<\/scp> concentrations in women with non\u2010cavity\u2010distorting intramural uterine fibroids"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1689-2782","authenticated-orcid":false,"given":"Alper","family":"Kahraman","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Haseki Training and Research Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1668-8746","authenticated-orcid":false,"given":"Firat","family":"Tulek","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Memorial Atasehir Hospital  Istanbul Turkey"},{"name":"Department of Midwifery Faculty of Health Sciences, Uskudar University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,17]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Mini\u2010combined test compared with NICE guidelines for early risk\u2010assessment for pre\u2010eclampsia: the SPREE diagnostic accuracy study","author":"Poon 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