{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T18:31:12Z","timestamp":1763058672182,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T00:00:00Z","timestamp":1645056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the roles of four selected genetic variations in fetal and maternal progesterone receptor gene (<jats:italic>PGR<\/jats:italic>) and to identify women who may have higher or lower odds for spontaneous premature birth compared to the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A preliminary case\u2013control study with two groups of pregnant women (with term and premature delivery, 218 in total) and two groups of newborns (term and preterm, 218 in total) was performed. Four single nucleotide polymorphisms (SNPs) of the progesterone receptor gene (rs1042838, rs1042839, rs10895068, and rs1942836) were genotyped.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was statistically significant difference between cases and controls in the distribution of newborns' allele frequency of minor C allele of the <jats:italic>PGR<\/jats:italic> SNP rs1942836 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.03, Fishers' exact test) in favor of premature birth. A statistically significant difference between the frequency of the mothers' minor T allele of rs1042838 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.005; chi\u2010squared test) and the mothers' minor T allele of rs1042839 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.005; chi\u2010squared test) in favor of extremely premature birth has been found. There was a statistically significant difference between the frequency of the newborns' minor C allele of rs1942836 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.03; chi\u2010squared test) and newborns' heterozygotes CT genotype of rs1942836 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.03; Fishers' exact test) when comparing the group of term births and the group of early premature birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study suggests that patients with selected genetic variants of the progesterone receptor gene could have greater odds for premature birth compared to term birth. Replication studies with a larger population and different ethnicity are needed in order to confirm these findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15194","type":"journal-article","created":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T05:33:48Z","timestamp":1645162428000},"page":"1099-1109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Progesterone receptor genetic variants in pregnant women and fetuses as possible predictors of spontaneous premature birth: A preliminary case\u2013control study"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3005-4571","authenticated-orcid":false,"given":"Mirta","family":"Kadivnik","sequence":"first","affiliation":[{"name":"Clinic of Obstetrics and Gynecology University Hospital Center Osijek  Osijek Croatia"},{"name":"Department of Obstetrics and Gynecology Faculty of Medicine, J.J. Strossmayer University  Osijek Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Kralik","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics and Informatics Faculty of Medicine, J.J. Strossmayer University  Osijek Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrijana","family":"Muller\u2010Vranje\u0161","sequence":"additional","affiliation":[{"name":"Clinic of Obstetrics and Gynecology University Hospital Center Osijek  Osijek Croatia"},{"name":"Department of Obstetrics and Gynecology Faculty of Medicine, J.J. Strossmayer University  Osijek Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Vu\u010demilovi\u0107\u2010Juri\u0107","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Genetics Faculty of Medicine, J.J. Strossmayer University  Osijek Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sini\u0161a","family":"\u0160ijanovi\u0107","sequence":"additional","affiliation":[{"name":"Clinic of Obstetrics and Gynecology University Hospital Center Osijek  Osijek Croatia"},{"name":"Department of Obstetrics and Gynecology Faculty of Medicine, J.J. Strossmayer University  Osijek Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1126-7523","authenticated-orcid":false,"given":"Jasenka","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Genetics Faculty of Medicine, J.J. 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