{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T17:59:12Z","timestamp":1776275952667,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the cost\u2010effectiveness of a strategy based on direct\u2010acting uterine curettage (UC) versus a pre\u2010direct\u2010acting misoprostol (1600\u00a0mg) in patients with missed abortion (MA), from the perspective of a National Health System.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An open prospective cohort study was carried out at Reina Sof\u00eda University Hospital (C\u00f3rdoba, Spain) from January 1, 2019 to December 31, 2019 in 180 patients diagnosed with MA. The patients chose medical treatment with intravaginal misoprostol (800\u2009\u03bcg\/4\u00a0h) or UC after receiving complete and detailed information. The effectiveness, clinical characteristics of the patients, costs of treating and managing the disease, and satisfaction with the procedures were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and forty\u2010five patients (80.6%) chose misoprostol versus 35 patients (19.4%) who chose UC. The effectiveness of misoprostol has been 42% evaluated at 48\u00a0h; UC success rate has been 100%. The incidence of side effects is significantly higher in patients treated with misoprostol (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05); as well as the number of care received by the patient (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Satisfaction is higher in patients treated with UC (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). However, the cost is almost 5\u2010folds higher in patients treated with UC (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>UC has a higher success rate, greater satisfaction, and a lower incidence of side effects, although significantly increases the cost compared to misoprostol in MA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15201","type":"journal-article","created":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T05:09:17Z","timestamp":1645852157000},"page":"1110-1115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Intravaginal misoprostol versus uterine curettage for missed abortion: A cost\u2010effectiveness analysis"],"prefix":"10.1111","volume":"48","author":[{"given":"Mar\u00eda Dolores","family":"Torres\u2010Miranda","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Reina Sof\u00eda University Hospital of C\u00f3rdoba  C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2231-3123","authenticated-orcid":false,"given":"Jorge","family":"Duro G\u00f3mez","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Reina Sof\u00eda University Hospital of C\u00f3rdoba  C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja","family":"Pe\u00f1a Lobo\u2010Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Reina Sof\u00eda University Hospital of C\u00f3rdoba  C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Jes\u00fas","family":"De la Torre Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Reina Sof\u00eda University Hospital of C\u00f3rdoba  C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9860-8318","authenticated-orcid":false,"given":"Camil","family":"Castelo\u2010Branco","sequence":"additional","affiliation":[{"name":"Clinic Institute of Gynecology Obstetrics and Neonatology, Faculty of Medicine\u2010 University of Barcelona, Hospital Clinic\u2010Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"International recommendations on definitions of live birth and fetal death","author":"OMS\/VVHO","year":"1950"},{"key":"e_1_2_8_3_1","unstructured":"Aborto espont\u00e1neo.Protocolo asistencial en obstetricia de la SEGO. 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