{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T12:17:39Z","timestamp":1775218659616,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T00:00:00Z","timestamp":1647561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This meta\u2010analysis was conducted to compare the effect and safety of oral contraceptive pills (OCP) plus orlistat with OCP alone in clinical, hormonal, and lipid metabolism outcomes in patients with polycystic ovary syndrome (PCOS) and overweight\/obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pubmed, Embase, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and SinoMed were systematically reviewed. A random\u2010effects or fixed\u2010effects model was used to pool the estimate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight studies were included in this meta\u2010analysis. Significant reductions in BMI, WHR, and waist circumference were observed in combination group as compared with OCP alone group. Regarding the hormonal outcome, T, SHBG, FAI, LH, DHEAS, FSH, and E2 levels were significantly improved in combination group compared with OCP alone group. However, the TT and FT did not change significantly between the two groups. Regarding the lipid metabolism outcomes, TC, LDL\u2010C, and TG levels were reduced and HDL\u2010C level was increased in the combination group. Regarding the insulin metabolism outcomes, FINS and HOMA\u2010IR levels were reduced in combination group than in OCP group. The ovulation rate, pregnancy rate, and overall effective rate were significantly higher in combination group than in OCP alone group. Fewer complications were observed in the combination group than in OCP group, and the difference between them was significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This combination treatment of OCP and orlistat was more effective than OCP alone in reducing the weight, hormonal, lipid, and insulin metabolism profiles, as well as improving the ovulation rate, pregnancy rate, and overall effective rate, as compared with OCP alone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15211","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T10:33:53Z","timestamp":1647599633000},"page":"1399-1408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effects of oral contraceptives plus orlistat in patients with polycystic ovary syndrome and overweight\/obesity: A meta\u2010analysis"],"prefix":"10.1111","volume":"48","author":[{"given":"Zhangming","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Reproductive Health and Infertility Gaozhou Hospital of Traditional Chinese Medicine  Gaozhou City Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0798-9072","authenticated-orcid":false,"given":"Zhaowei","family":"Cai","sequence":"additional","affiliation":[{"name":"Reproductive Center SSL Central Hospital of Dongguan  Dongguan City Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,18]]},"reference":[{"issue":"6","key":"e_1_2_8_2_1","first-page":"661","article-title":"Polycystic ovarian syndrome: clinical and biological diagnosis","volume":"74","author":"Bachelot A","year":"2016","journal-title":"Ann Biol Clin"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.05.003"},{"issue":"4","key":"e_1_2_8_4_1","first-page":"279","article-title":"Polycystic ovary syndrome and metabolic syndrome","volume":"80","author":"Ali AT","year":"2015","journal-title":"Ceska Gynekol"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000345310"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa063971"},{"issue":"8","key":"e_1_2_8_7_1","first-page":"Cd005552","article-title":"Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary syndrome","volume":"8","author":"Fraison E","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.5812\/ijem.2920"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12578"},{"issue":"4","key":"e_1_2_8_10_1","first-page":"199","article-title":"Computed tomography study of the effect of orlistat on visceral adipose tissue volume in obese subjects","volume":"12","author":"Dicker D","year":"2010","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_8_13_1","unstructured":"WellsG SheaB O'connellD et al.The Newcastle\u2010Ottawa scale (NOS) for assessing the quality of nonrandomized studies in meta\u2010analyses. 2008. 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