{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:13:40Z","timestamp":1791252820964,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Ovarian torsion is a common cause of local ischemic damage, reduced follicular activity and infertility. This study aimed to investigate how well platelet\u2010rich plasma (PRP) protects against experimental ischemic (I) and ischemia\u2010reperfusion (I\/R) injury in rat ovaries and its effect on in vitro fertilization (IVF) outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Fifty\u2010six adult female Sprague\u2013Dawley albino rats were randomly assigned to six groups of eight animals each: Sham, Ischemia, I\/R, Sham + PRP, I\u2009+\u2009PRP, and I\/R\u2009+\u2009PRP. The remaining eight animals were used to prepare the PRP. The ischemia groups were subjected to bilateral adnexal torsion for 3\u00a0h, while the I\/R and I\/R\u2009+\u2009PRP groups received subsequent detorsion for 3\u00a0h. Intraperitoneal (i.p.) PRP was administered 30\u2009min prior to ischemia (I\u2009+\u2009PRP) or reperfusion (I\/R\u2009+\u2009PRP). The ovaries were stimulated through an intraperitoneal injection of 150\u2013300 internal units of IU\/kg PMSG. After ovulation induction, oocytes were taken from the ovaries, and IVF was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The number of MII oocytes reached the highest number with 4.63\u2009\u00b1\u20090.74 in the S group and had the lowest number with 0.50\u2009\u00b1\u20090.53 in the I\/R group. There were statistically significant differences for the number of embryos obtained on the second day between the I and I\u2009+\u2009PRP groups and the I\/R and I\/R\u2009+\u2009PRP groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.000). In comparing anti\u2010M\u00fcllerian hormone 1 (AMH1) and AMH2 values within the group, the highest decrease was observed in the I and I\/R groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PRP is effective in minimizing ovarian damage and preserving ovarian reserves following ovarian torsion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15232","type":"journal-article","created":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T22:49:36Z","timestamp":1648162176000},"page":"1390-1398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The effect of protection of platelet\u2010rich plasma against experimental ischemia\/reperfusion injury in the rat ovary on in vitro fertilization outcomes"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4776-6244","authenticated-orcid":false,"given":"Mehmet 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