{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:35:06Z","timestamp":1747186506928,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:00:00Z","timestamp":1648512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We present two cases of triplet pregnancy with complete hydatidiform mole (CHM) in contrasting outcomes and discuss the complications of mothers and outcomes of fetuses through a literature review, raising an important issue on the management of this special pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We share our manage experience for two cases of triplet pregnancy with CHM and retrospectively analyze 18 similar pregnancies reported previously with different pregnancy outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In our cases, one case receiving Clomiphene ovulation induction delivered two live fetuses by cesarean section at 30+ weeks without GTN (gestational trophoblastic neoplasia), unfortunately, the other case following ICSI\u2010ET terminated the pregnancy in the setting of complications at 18+ weeks without GTN. No severe complications were detected during pregnancy and no pGTD was developed after delivery in neither of the pregnant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Co\u2010existing complete hydatidiform mole in multiple pregnancies may become more common owing to the spreading use of ART. The decision for whether continue pregnancy depending on the personalized conditions including the complications of the pregnancy, the outcomes of the fetuses, the gestational age for delivery, and the potential progression of persistent gestational trophoblastic disease (pGTD). Furthermore, close monitor is necessary for the pregnant with triplet pregnancy with CHM who want to continue pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15243","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T01:39:41Z","timestamp":1648604381000},"page":"1458-1465","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Triplet pregnancy with hydatidiform mole: A report of two cases with literature review"],"prefix":"10.1111","volume":"48","author":[{"given":"Qing\u2010Jing","family":"Sheng","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Mei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bei\u2010Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Shuai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9350-8721","authenticated-orcid":false,"given":"Xiao\u2010Ying","family":"He","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(03)01245-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2018.1438653"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.06.073"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09085-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2000.tb11663.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01138658"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(92)91694-6"},{"issue":"9","key":"e_1_2_8_9_1","first-page":"600","article-title":"Recurrent molar pregnancy after ovulation induction and repeat ovulation induction. A case report","volume":"42","author":"Ba\u015fbu\u011f M","year":"1997","journal-title":"J Reprod Med"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/13645706.2015.1074082"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2017.01.021"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.3.608"},{"key":"e_1_2_8_13_1","unstructured":"WHO Scientific Group.Gestational Trophoblastic Disease. World Health Organization Technical Report Series.1983."},{"issue":"1","key":"e_1_2_8_14_1","first-page":"35","article-title":"Natural history of twin pregnancy with complete hydatidiform mole and coexisting fetus","volume":"83","author":"Steller MA","year":"1994","journal-title":"Obstet Gynecol"},{"key":"e_1_2_8_15_1","unstructured":"FoskettMA SecklMJ ParadinasFJ FrancisR ShortD FullerS&NewlandsESA review of 126 cases registered at Charing Cross Hospital as twin\/multiple pregnancies complicated by a complete hydatidiform mole in IXth World Congress on Gestational Trophoblastic Diseases. 1998: Israel."},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(75)90165-9"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(82)90445-8"},{"issue":"1","key":"e_1_2_8_18_1","first-page":"129","article-title":"Hydatidiform mole with coexistent fetus","volume":"60","author":"Block MF","year":"1982","journal-title":"Obstet Gynecol"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(76)90652-9"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-004-0642-x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2013.02.005"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2000.5733"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2019.100519"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2017.03.013"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/plac.2000.0613"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1994.1311"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4004(87)90056-7"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.15243","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.15243","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.15243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T19:52:29Z","timestamp":1692820349000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.15243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,29]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1111\/jog.15243"],"URL":"https:\/\/doi.org\/10.1111\/jog.15243","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"type":"print","value":"1341-8076"},{"type":"electronic","value":"1447-0756"}],"subject":[],"published":{"date-parts":[[2022,3,29]]},"assertion":[{"value":"2022-01-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}