{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T15:51:41Z","timestamp":1750175501135,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T00:00:00Z","timestamp":1649721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Our aim in this study was to evaluate the effect of antiepileptic drugs on biochemical components of screening tests.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:roman>Materials and Methods<\/jats:roman><\/jats:title><jats:p>This longitudinal case\u2013control study was performed at Ankara City Hospital, Ankara, Turkey, from June 2020 to January 2021. The case group included epileptic singleton pregnant women which were using antiepileptic drugs, between 18 and 44\u2009years of age. The control group included healthy pregnant women between 18 and 44\u2009years old who did not use any drugs. Maternal medical, obstetric, and gynecological history were recorded. The antiepileptic agents that are used in our study were; lamotrigine, levetiracetam, carbamazepine, oxcarbazepine, valproic acid, and clonazepam. For the aneuploidy screening program conducted in our laboratory, the biochemical markers that are analyzed include; free b\u2010hCG and PAPP\u2010A in the first trimester, as well as AFP, HCG, and unconjugated estriol (uE3) in the second trimester. MoM values of these markers were compared between the case and control groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010three pregnant women with epilepsy using antiepileptic drugs were compared with 106 healthy pregnant women. The levels of serum\u2010free b\u2010hCG, and PAPP\u2010A were similar between the case and control groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.653, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.351). For the second\u2010trimester screening biochemical markers, the maternal serum uE3 and AFP levels expressed as MoM were significantly higher in the epileptic group than in the control patients (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.015 and <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum marker levels of second\u2010trimester screening tests may be affected by antiepileptic drugs, which may lead to misinterpretation of the risk level. Antiepileptic drug usage should be considered when evaluating screening test results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15250","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T11:13:57Z","timestamp":1649762037000},"page":"1607-1612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of antiepileptic drugs on serum biochemical marker levels of first and second trimester screening tests"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0376-2513","authenticated-orcid":false,"given":"Berhan","family":"Besimoglu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Perinatology Ankara City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4727-7982","authenticated-orcid":false,"given":"Fatma 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