{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T09:20:49Z","timestamp":1771492849062,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T00:00:00Z","timestamp":1650672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the efficacy of short\u2010term administration of relugolix, a novel orally active gonadotropin\u2010releasing hormone (GnRH) antagonist, before single\u2010port laparoscopic\u2010assisted vaginal hysterectomy (LAVH) for symptomatic uterine myomas, retrospectively compared with injection of leuprorelin, a GnRH agonist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective comparative study of each 35 women with symptomatic myomas in the relugolix and leuprorelin groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Before administration of relugolix and leuprorelin, the median uterine volume did not differ significantly between the two groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.53). Median uterine volume change from baseline after short\u2010term administration of relugolix and leuprorelin did not differ significantly (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.17). Surgical duration (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.84) and estimated blood loss (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.48) were not different between the two groups. According to a patient questionnaire, the side effects of the drugs were not different between the two groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.27). When patients were was asked if they wanted to have either of these drugs again, some relugolix users preferred leuprorelin due to concern about forgetting daily medication, while some leuprorelin users preferred relugolix to avoid pain at injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Oral relugolix medication or leuprorelin injection administered before single\u2010port LAVH for uterine myomas yielded an equivalent reduction of uterine volume and perioperative outcomes with no significant adverse events. Patient preference for either oral daily relugolix or a monthly injection of leuprorelin could be considered when preoperative management is determined.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15269","type":"journal-article","created":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T10:59:32Z","timestamp":1650711572000},"page":"1921-1929","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Short\u2010term administration of oral relugolix before single\u2010port laparoscopic\u2010assisted vaginal hysterectomy for symptomatic uterine myomas: A retrospective comparative study with leuprorelin injection"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6392-7845","authenticated-orcid":false,"given":"Akihiro","family":"Takeda","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Gifu Prefectural Tajimi Hospital  Tajimi Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2005.09.012"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000547.pub2"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/grf.0000000000000664"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2016.06.006"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2008283"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.07.013"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000003141"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2007.10.020"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.4293\/JSLS.2019.00019"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S147318"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2004.00504.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.08.062"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.15269","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.15269","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.15269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T06:59:23Z","timestamp":1692946763000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.15269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,23]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/jog.15269"],"URL":"https:\/\/doi.org\/10.1111\/jog.15269","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,23]]},"assertion":[{"value":"2022-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}