{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T08:01:17Z","timestamp":1774771277675,"version":"3.50.1"},"reference-count":63,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Lynch syndrome (LS) is one of the most common hereditary cancer syndromes, characterized by mutations in mismatch repair genes and autosomal dominant inheritance. Women with LS have an additional increased risk of gynecologic malignancies, including endometrial cancer (EC) and ovarian cancer (OC). Compared with EC, OC is relatively under investigation. This review thoroughly summarizes the current clinical evidence of surveillance, screening, and prevention strategies, and describes the molecular and clinical characteristics of LS\u2010associated OC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An electronic search from databases of PubMed and Google Scholar was carried out using key words pertaining to Lynch syndrome and ovarian cancer. A review of the literatures including review articles, experimental, and observational studies published between 2000 and 2021 was conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The lifetime risk of OC in women with LS of <jats:italic>MLH1<\/jats:italic>, <jats:italic>MSH2<\/jats:italic>, and <jats:italic>MSH6<\/jats:italic> mutations is approximately 7%, with the median age at onset being 46\u2009years, 10\u201315\u2009years earlier than that in sporadic cases. Histologically, LS\u2010associated OCs are primarily endometrioid (40%), high\u2010grade (25%), and low\u2010grade (11%) serous, or clear cell (6%) in nature. Eighty\u2010five percent of patients are diagnosed at an early stage, presenting with a good prognosis at 84% 5\u2010year survival. Optimal screening strategies for OC in LS are controversial; combined screening of patients' clinical and family history, immunohistochemical analysis, and microsatellite instability testing for mismatch repair deficiency have been proven efficient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The clinical features were different between ovarian cancer in Lynch syndrome and sporadic cases. More research are needed for a greater understanding of the prevention and medical treatment of LS\u2010associated OC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15273","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T05:44:35Z","timestamp":1651124675000},"page":"1538-1545","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The clinical features and management of Lynch syndrome\u2010associated ovarian cancer"],"prefix":"10.1111","volume":"48","author":[{"given":"Xuting","family":"Ran","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics West China Second University Hospital, Sichuan University  Chengdu P.R. China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education  Chengdu P.R. 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