{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T09:04:10Z","timestamp":1774343050921,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To investigate the vaccination status and adverse reactions to the COVID\u201019 vaccine among pregnant women in Japan, we conducted an online questionnaire survey from October 5 to November 22, 2021. The number of participants in the online survey was 6576. Of the participants, 4840 (73.6%) were vaccinated twice, and 557 (8.5%) were vaccinated once. A total of 1179 (17.9%) responders had never been vaccinated against COVID\u201019. The most frequent adverse reaction was local pain at the injection site. The incidence of local adverse reactions was almost identical after the first and the second vaccinations, while systemic reactions, such as fever and fatigue\/malaise, and adverse reactions outside the vaccination site such as headache and arthralgia, were more frequent after the second vaccination than after the first vaccination. Regarding the obstetrical complications, uterine tension and\/or contraction was observed in 1.65% of the pregnant women after the first vaccination and in 2.98% after the second vaccination, and uterine pain appeared in 1.06% of the pregnant women after the second vaccination. However, serious symptoms, such as hemorrhage, decreased fetal movement, edema, increased blood pressure, and amniorrhexis, were seen in less than 1% of vaccinated women after both the first and second vaccinations. This study clarified the characteristics of vaccination, adverse reactions, and obstetrical symptoms in pregnant women in Japan who had the COVID\u201019 vaccine up to the second dose. As a booster vaccination is currently underway, further study is needed to improve the management of pregnant women during the current pandemic.<\/jats:p>","DOI":"10.1111\/jog.15285","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:49:37Z","timestamp":1652230177000},"page":"1561-1569","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The vaccination status and adverse effects of <scp>COVID<\/scp>\u201019 vaccine among pregnant women in Japan in 2021"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9417-0315","authenticated-orcid":false,"given":"Shihoko","family":"Komine\u2010Aizawa","sequence":"first","affiliation":[{"name":"Division of Microbiology, Department of Pathology and Microbiology Nihon University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6865-5159","authenticated-orcid":false,"given":"Yasuo","family":"Haruyama","sequence":"additional","affiliation":[{"name":"Integrated Research Faculty for Advanced Medical Sciences Dokkyo Medical University  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Deguchi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1022-1443","authenticated-orcid":false,"given":"Satoshi","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Division of Microbiology, Department of Pathology and Microbiology Nihon University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1919-8830","authenticated-orcid":false,"given":"Kei","family":"Kawana","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology Nihon University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen","family":"Kobashi","sequence":"additional","affiliation":[{"name":"Department of Public Health Dokkyo Medical University  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5492-0844","authenticated-orcid":false,"given":"Etsuko","family":"Miyagi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yokohama City University Hospital  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideto","family":"Yamada","sequence":"additional","affiliation":[{"name":"Center for Recurrent Pregnancy Loss Teine Keijinkai Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3715-0075","authenticated-orcid":false,"given":"Takashi","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ehime University Graduate School of Medicine  Toon Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,10]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"CDC.Evidence for conditions that increase risk of severe illness 2021 Published online: E\u2010Pub."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2104983"},{"key":"e_1_2_9_4_1","unstructured":"CDC.COVID\u201019 vaccines while pregnant or breastfeeding. Available from:https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/vaccines\/recommendations\/pregnancy.html. Accessed 22 February."},{"key":"e_1_2_9_5_1","unstructured":"WHO.The Pfizer BioNTech (BNT162b2) COVID\u201019 vaccine: What you need to know. Available from:https:\/\/www.who.int\/news-room\/feature-stories\/detail\/who-can-take-the-pfizer-biontech-covid-19--vaccine-what-you-need-to-know. Accessed 22 February."},{"key":"e_1_2_9_6_1","unstructured":"WHO.The Moderna COVID\u201019 (mRNA\u20101273) vaccine: what you need to know. Available from:https:\/\/www.who.int\/news-room\/feature-stories\/detail\/the-moderna-covid-19-mrna-1273-vaccine-what-you-need-to-know. Accessed 22 February."},{"key":"e_1_2_9_7_1","unstructured":"Japan Society of Obstetrics and Gynecology. Available from:https:\/\/www.jsog.or.jp\/news\/pdf\/20210814_COVID19_02.pdf. Accessed 22 February."},{"key":"e_1_2_9_8_1","unstructured":"Japan Association of Obstetricians and Gynecologist. Available from:https:\/\/www.jaog.or.jp\/wp\/wp-content\/uploads\/2021\/08\/210814.pdf. Accessed 22 February."},{"key":"e_1_2_9_9_1","unstructured":"Japan Society for Infection Diseases in Obstetrics and Gynecology. Available from:http:\/\/jsidog.kenkyuukai.jp\/images\/sys\/information\/20210816102601\u2010DCA4B5C45C25B46F8589FEF7A441A12F2E6DAD7AA278B25E18D9D1C303015C8D.pdf. Accessed 22 February."},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2022.100313"},{"key":"e_1_2_9_11_1","unstructured":"CDC.COVID\u201019 vaccination among pregnant people aged 18\u201349\u2009years overall by race\/ethnicity and date reported to CDC \u2010 Vaccine Safety Datalink United States. Available from:https:\/\/covid.cdc.gov\/covid-data-tracker\/#vaccinations-pregnant-women. Accessed on 22 February."},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgwh.2021.761511"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2021.36.e153"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m3320"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01666-2"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.15285","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.15285","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.15285","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T06:58:28Z","timestamp":1692946708000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.15285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,10]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/jog.15285"],"URL":"https:\/\/doi.org\/10.1111\/jog.15285","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,10]]},"assertion":[{"value":"2022-02-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}