{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T20:16:22Z","timestamp":1770236182516,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T00:00:00Z","timestamp":1652745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myoepithelioma\u2010like tumors of the vulvar region (MELTVR) is a kind of solid tumor newly recognized in recent years, which is characterized by mesenchymal tumors of adult female vulva. The histopathology is similar to myoepithelioma, but the immunohistochemical phenotype and genetic changes are different from myoepithelioma. It usually has clear boundary and partial capsule, mixed with two forms of cells (epithelioid and spindle), the cells are mild, the nucleoli are clear, mitoses are rare, some cases have myxoid differentiation. In this article, a case of MELTVR diagnosed in our hospital is discussed. The patient was a 43\u2010year\u2010old female who finds a neoplasm in the pubic tubercle 4\u2009months ago. Local resection was performed. Pathological examination showed that the boundary of the tumor was clear with partial capsule. The cells were arranged in cords or nests, and partially infiltrated the surrounding adipocytes. The tumor cells had two morphologies, epithelioid or spindle shaped. The spindle type cells were dominant, with bright cytoplasm, obvious nucleoli, rare nuclear mitosis (about 1\/10HPF), and no necrosis was observed. Immunohistochemically, the tumor cells were positive for vimentin, epithelial membrane antigen, estrogen receptor, progestogen receptor, calponin and were partially positive for cathepsin k. INI1\/SMARCB1 expression was deficient. There was no recurrence or metastasis during the 8\u2010month\u2010long follow\u2010up. The unique feature of this case was that the site of the disease was not the vulva, but in front of the pubic tubercle, there was no large amount of mucus production, and the cytoplasm of most tumor cells was transparent. Due to our limited knowledge of MELTVR, its pathogenesis and tissue origin are not clear. Clinicians should be aware of such potential patients.<\/jats:p>","DOI":"10.1111\/jog.15286","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T03:44:16Z","timestamp":1652845456000},"page":"2015-2020","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Myoepithelioma\u2010like tumors of the vulvar region: A case report and review of the literature"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3138-5241","authenticated-orcid":false,"given":"Xu","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Pathology China Three Gorges University  Yichang China"},{"name":"Department of Pathology Yichang Central People's Hospital  Yichang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Pathology China Three Gorges University  Yichang China"},{"name":"Department of Pathology Yichang Central People's Hospital  Yichang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics the People's Hospital of China Three Gorges University  Yichang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Affiliated Renhe Hospital of China Three Gorges University  Yichang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuchang","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of Pathology China Three Gorges University  Yichang China"},{"name":"Department of Pathology Yichang Central People's Hospital  Yichang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000397"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000466"},{"key":"e_1_2_8_4_1","volume-title":"WHO Classification of Tumours of Soft Tissue and Bone","year":"2020"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-018-0049-z"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000102"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13173"},{"issue":"10","key":"e_1_2_8_8_1","first-page":"1055","article-title":"Clinicopathological features of myoepithelioma\u2010like tumors of the vulvar region","volume":"49","author":"Li X","year":"2020","journal-title":"Zhonghua Bing Li Xue Za 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