{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:41:41Z","timestamp":1761514901383,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to assess the in vitro fertilization (IVF) treatments outcomes of women with recurrent implantation failure (RIF) after hysteroscopic isthmoplasty for isthmocele.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective, observational study included 61 patients with RIF and isthmocele who presented to IVF Unit of H\u00fcma Obstetrics and Gynecology Hospital between January, 2018 and December, 2020. Thirty\u2010one patient who underwent hysteroscopic isthmoplasty\u2014before IVF procedure\u2014were included. Remaining 30 patients underwent IVF without hysteroscopic isthmoplasty were included as controls. The fertility outcome were compared between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 3\u00a0months, spontaneous pregnancy was achieved in 18.4% (7\/38) of patients with isthmocele who underwent hysteroscopic isthmoplasty. In the isthmoplasty group, implantation rate, clinical pregnancy rate, biochemical pregnancy rate, and the miscarriage rate were 41.9% (13\/31), 35.5% (11\/31), 6.5% (2\/31), and 9.7% (3\/31), respectively. The live birth rate after in vitro fertilization was 25.8% (8\/31) in the isthmoplasty group and 3.3% (1\/30) in the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). There were no significant differences in the IVF outcomes such as the biochemical pregnancy rate and miscarriage rate between the isthmoplasty and control groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrated that hysteroscopic isthmoplasty improves pregnancy and live birth rates for women with a history of RIF and isthmocele. Reproductive results of the IVF cycles after hysteroscopic correction of isthmocele were comparable to those of the patients without any uterine abnormalities and those with diagnosis of unexplained infertility.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15317","type":"journal-article","created":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T01:33:21Z","timestamp":1653701601000},"page":"1829-1835","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Assessment of in vitro fertilization outcomes after hysteroscopic isthmoplasty in recurrent implantation failure"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5092-1364","authenticated-orcid":false,"given":"Ahmet Emin","family":"Mutlu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology H\u00fcma Obstetrics and Gynecology Hospital, IVF Center  Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,27]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"SimsekE.Tekrarlayan \u0130mplantasyon Ba\u015far\u0131s\u0131zl\u0131\u011f\u0131 G\u00fcncel Durum. [Cited 10 Nov 2022.] Available fromhttps:\/\/www.tsrm.org.tr\/pro\/egitim\/tsrm\u2010derlemeler\/tekrarlayan\u2010implantasyon\u2010basarisizligi\u2010guncel\u2010durum"},{"volume-title":"Anatomi","year":"1999","author":"Ar\u0131nc\u0131 K","key":"e_1_2_8_3_1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)44710-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a138451"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(16)33287-2"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13518"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12542"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.65.5.714"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e3283521202"},{"issue":"4","key":"e_1_2_8_11_1","first-page":"32","article-title":"Cesarean scar defect: what is it and how should it be treated?","volume":"28","author":"Nezhat CM","year":"2016","journal-title":"Obg Manag"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.01.037"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2003.22.7.695"},{"issue":"4","key":"e_1_2_8_14_1","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1016\/S1074-3804(96)80170-8","article-title":"Hysteroscopic correction of cesarean section scars in women with abnormal uterine bleeding","volume":"3","author":"Fernandez E","year":"1996","journal-title":"J Am Assoc Gynecol Laparosc"},{"issue":"12","key":"e_1_2_8_15_1","first-page":"2695","article-title":"Why do niches develop in caesarean uterine scars? Hypotheses on the aetiology of niche development","volume":"30","author":"Vervoort AJ","year":"2015","journal-title":"Hum Reprod"},{"key":"e_1_2_8_16_1","first-page":"1765624","article-title":"Efficacy of combined laparoscopic and Hysteroscopic repair of post\u2010cesarean section uterine diverticulum: a retrospective analysis","volume":"2016","author":"Li C","year":"2016","journal-title":"Biomed Res Int"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2010.02.007"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.advms.2017.01.004"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.06.035"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2007.10.004"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2001.20.10.1105"},{"issue":"15","key":"e_1_2_8_22_1","first-page":"3341","article-title":"Clinical outcomes after resectoscopic treatment of cesarean\u2010induced isthmocele: a prospective case\u2010control study","volume":"21","author":"Muzii L","year":"2017","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13199"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2016.06.020"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2013.03.008"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2004.12.023"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6405"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)61108-X"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.15317","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.15317","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.15317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T06:58:38Z","timestamp":1692946718000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.15317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,27]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/jog.15317"],"URL":"https:\/\/doi.org\/10.1111\/jog.15317","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"type":"print","value":"1341-8076"},{"type":"electronic","value":"1447-0756"}],"subject":[],"published":{"date-parts":[[2022,5,27]]},"assertion":[{"value":"2022-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}