{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:10:40Z","timestamp":1785499840701,"version":"3.56.0"},"reference-count":87,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20ek0109483"],"award-info":[{"award-number":["JP20ek0109483"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007786","name":"National Center for Child Health and Development","doi-asserted-by":"publisher","award":["2020B\u20106"],"award-info":[{"award-number":["2020B\u20106"]}],"id":[{"id":"10.13039\/100007786","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007786","name":"National Center for Child Health and Development","doi-asserted-by":"publisher","award":["2021B\u20105"],"award-info":[{"award-number":["2021B\u20105"]}],"id":[{"id":"10.13039\/100007786","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To review new challenges of fetal therapy in Japan after the establishment of four existing fetal therapies as standard prenatal care with National Health Insurance coverage over the past 20\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Reported studies and our current research activities related to four fetal therapies newly performed in Japan were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fetoscopic endoluminal tracheal occlusion (FETO) for congenital diaphragmatic hernia (CDH) aims to occlude the trachea using a detachable balloon to promote lung growth. Following the recent successful completion of an international randomized controlled trial for CDH, in which we participated, FETO is offered for severe left CDH to perform balloon insertion at 27\u201329\u2009weeks and removal at 34\u2009weeks of gestation. Fetal cystoscopy (FC) for low urinary tract obstruction was introduced to overcome the demerits of vesicoamniotic shunting. FC may provide a proper diagnosis by visual observation of the urethra and physiological treatment of the posterior urethral valve. The effectiveness of open fetal surgery for myelomeningocele (MMC), direct surgery with laparotomy and hysterotomy, for ameliorating hindbrain herniation and the motor function was demonstrated, but it was also associated with substantial maternal and fetal risks. Fetal aortic valvuloplasty (FAV), ultrasound\u2010guided fetal aortic balloon dilation for critical aortic stenosis with evolving hypoplastic left heart syndrome may improve left heart development and maintain biventricular circulation. Feasibility and safety studies for FC, MMC open fetal surgery, and FAV are currently ongoing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Clinical research on FETO, FC, MMC open fetal surgery, and FAV has proceeded with careful preparations in Japan.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15320","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T03:14:27Z","timestamp":1654744467000},"page":"2100-2111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["New challenges of fetal therapy in Japan"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8654-6623","authenticated-orcid":false,"given":"Seiji","family":"Wada","sequence":"first","affiliation":[{"name":"Center for Maternal\u2010Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8728-5576","authenticated-orcid":false,"given":"Katsusuke","family":"Ozawa","sequence":"additional","affiliation":[{"name":"Center for Maternal\u2010Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9387-1849","authenticated-orcid":false,"given":"Haruhiko","family":"Sago","sequence":"additional","affiliation":[{"name":"Center for Maternal\u2010Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5365.1107"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198212233072623"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.284.6313.373"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(16)32377-8"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198810273191706"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.65.5.256"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.125242"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(88)80325-7"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199005313222207"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(93)90332-F"},{"key":"e_1_2_11_12_1","first-page":"1046","article-title":"Fetoscopic neodymium:YAG laser occlusion of placental vessels in severe twin\u2010twin transfusion syndrome","volume":"75","author":"De Lia JE","year":"1990","journal-title":"Obstet Gynecol"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199501263320404"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1998.tb10132.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032597"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035005"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1711"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.5507\/bp.2017.023"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014379"},{"key":"e_1_2_11_20_1","first-page":"621","article-title":"Intrauterine intravascular fetal transfusion under ultrasonic guide in Rh isoimmunization: a case report","volume":"41","author":"Tanigawara S","year":"1989","journal-title":"Nihon Sanka Fujinka Gakkai Zasshi"},{"key":"e_1_2_11_21_1","first-page":"225","article-title":"Clinical aspects of fetal obstructive uropathy with in\u2010utero estimation of renal\u2010function and intrauterine shunt placement","volume":"3","author":"Chiba Y","year":"1993","journal-title":"J Matern Fetal Invest"},{"key":"e_1_2_11_22_1","first-page":"117","article-title":"A case of twin\u2010twin transfusion syndrome treated with placental vessel occlusion using fetoscopic Nd:YAG laser system","volume":"44","author":"Natori M","year":"1992","journal-title":"Nihon Sanka Fujinka Gakkai Zasshi"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2647"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13600"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4357"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2016.06.002"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14922"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12827"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000486130"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1017\/thg.2020.94"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5726"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3994"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4989"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5066"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4800"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1159\/000442152"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6048"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.2020.63.2.108"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14047"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14746"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/00132584-200110000-00004"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3863"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.3.532"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2012.12.017"},{"issue":"227","key":"e_1_2_11_45_1","first-page":"vii","article-title":"A history of fetal surgery","volume":"36","author":"Jancelewicz T","year":"2009","journal-title":"Clin Perinatol"},{"key":"e_1_2_11_46_1","first-page":"452","article-title":"Fetal tracheal ligation and lung development","volume":"109","author":"Carmel JA","year":"1965","journal-title":"Am J Dis Child"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(94)90328-X"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(97)90472-3"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12445"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6450"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-010-2805-0"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-010-2725-z"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8892"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14504"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2027030"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2026983"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.11.1351"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1074"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2736"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2016.09.003"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60992-7"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1555704"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14908"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91381-5"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14652"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4771"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1159\/000500569"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14734"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/cga.12333"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(97)90603-5"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199510000-00001"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1159\/000028645"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)00070-1"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.19.1819"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.19.1826"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1159\/000118926"},{"key":"e_1_2_11_77_1","first-page":"67","article-title":"Open fetal surgery for congenital cystic adenomatoid malformation complicated with fetal hydrops\u2014a case report","volume":"41","author":"Kitano Y","year":"2005","journal-title":"J Japan Society Perinatal Neonatal Med"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.13889"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(89)90226-X"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2005.08.006"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60563-8"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-1592"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1995.05020090.x"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)00733-5"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8927"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.24792"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.119.006127"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.05.037"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.15320","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.15320","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.15320","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T02:46:44Z","timestamp":1692758804000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.15320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,8]]},"references-count":87,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1111\/jog.15320"],"URL":"https:\/\/doi.org\/10.1111\/jog.15320","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,8]]},"assertion":[{"value":"2022-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}