{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:34:33Z","timestamp":1761989673445,"version":"3.40.5"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T00:00:00Z","timestamp":1655856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There have been a large number of epidemiologic studies regarding the association between genetic polymorphisms in DNA repair genes and onset of cervical cancer. However, results are inconsistent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Articles published before June 2021 and regarding genetic polymorphisms in DNA repair genes and cervical cancer were searched in following databases: PubMed, Web of Science, Google Scholar, and CNKI. With at least three articles for each polymorphism, we made meta\u2010analysis to compute multivariate odds ratios (ORs) and their 95% confidence intervals (CIs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The present study showed significant associations between XRCC1 Arg399Gln polymorphisms and risk of cervical cancer in Asian, whereas no significant association between them were showed in Caucasian (Asian: GA vs. GG: OR\u2009=\u20091.27, 95%CI 1.06\u20131.52; AA vs. GG: OR\u2009=\u20091.91, 95%CI 1.29\u20132.83; GA\u2009+\u2009AA vs. GG: OR\u2009=\u20091.36, 95%CI 1.12\u20131.65; AA vs. GG\u2009+\u2009GA: OR\u2009=\u20091.66, 95%CI 1.17\u20132.37; Caucasian: GA vs. GG: OR\u2009=\u20091.08, 95%CI 0.83\u20131.41; AA vs. GG: OR\u2009=\u20092.18, 95%CI 0.75\u20136.31; GA\u2009+\u2009AA vs. GG: OR\u2009=\u20091.23, 95%CI 0.85\u20131.78; AA vs. GG\u2009+\u2009GA: OR\u2009=\u20091.70, 95%CI 0.69\u20134.18). In addition, there were significant associations between ERCC2 rs13181 polymorphisms and risk of cervical cancer in Asian (AC vs AA: OR\u2009=\u20090.53, 95%CI 0.37\u20130.75, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.0%, <jats:italic>p<\/jats:italic> value of Q test\u2009=\u20090.847; AC\u2009+\u2009CC vs AA: OR\u2009=\u20090.50, 95%CI 0.36\u20130.70, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.0%, <jats:italic>p<\/jats:italic> value of Q test\u2009=\u20090.856).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The meta\u2010analysis showed that there were significant associations between XRCC1 Arg399Gln and ERCC2 rs13181 polymorphisms and risk of cervical cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15325","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T02:39:46Z","timestamp":1655951986000},"page":"2405-2418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Genetic polymorphisms in <scp>DNA<\/scp> repair genes and their association with risk of cervical cancer: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"48","author":[{"given":"Xueting","family":"Shao","sequence":"first","affiliation":[{"name":"Nanjing University of Chinese Medicine  Nanjing Jiangsu China"},{"name":"Department of Gynaecology Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaole","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Suzhou TCM Hospital Affiliated to Nanjing 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Jiangsu China"},{"name":"Department of Gynaecology Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine  Suzhou Jiangsu 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