{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T02:26:39Z","timestamp":1783995999974,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T00:00:00Z","timestamp":1655683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Antenatal suspicion of placenta accreta spectrum (PAS) currently relies on ultrasonographic findings, color doppler, and MRI, which have rendered it operator and expertise\u2010dependent. No serum markers for PAS have been integrated into clinical practice yet. The aim of this meta\u2010analysis was to identify potential serum markers for PAS by investigating third\u2010trimester serum levels of vascular endothelial growth factor (VEFG), placental growth factor (PIGF), and soluble Fms\u2010like tyrosine kinase\u20101 (sFlt\u20101) among PAS\u2010cases and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed, Scopus, EBSCO, Web of Science, and CNKI databases were systematically searched for relevant articles. Random\u2010effects model was applied to calculate the overall standardized mean difference (SMD) for each marker. Subgroup analysis and meta\u2010regression were performed to assess for potential covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight studies involving 366 PAS\u2010cases and 518 controls were included. Third trimester sFlt\u20101 levels were significantly lower in PAS\u2010cases when compared to controls (SMD\u00a0=\u00a0\u22127.76, 95%CI\u00a0=\u00a0\u221210.42 to \u22125.10). This was, to a certain extent, consistent among studies though they differed in their extent of significance. Levels of VEGF (SMD\u00a0=\u00a01.59, 95%CI\u00a0=\u00a0\u22120.07 to 3.25) and PlGF (SMD\u00a0=\u00a0\u22120.49, 95%CI\u00a0=\u00a0\u22121.66 to 0.67) were not significantly different between PAS cases and controls, in which studies demonstrated conflicting results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Third trimester sFlt\u20101 levels may be useful to predict PAS. Nonetheless, further studies are recommended to better understand conflicting results before adopting either VEGF or PlGF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15330","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T03:09:36Z","timestamp":1655780976000},"page":"2363-2376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association between placenta accreta spectrum and third\u2010trimester serum levels of vascular endothelial growth factor, placental growth factor, and soluble Fms\u2010like tyrosine kinase\u20101: A meta\u2010analysis"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8196-3922","authenticated-orcid":false,"given":"Osama","family":"Alzoubi","sequence":"first","affiliation":[{"name":"School of Medicine The University of Jordan  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4574-8114","authenticated-orcid":false,"given":"Ward","family":"Maaita","sequence":"additional","affiliation":[{"name":"School of Medicine The University of Jordan  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5321-2774","authenticated-orcid":false,"given":"Zaid","family":"Madain","sequence":"additional","affiliation":[{"name":"School of Medicine The University of Jordan  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2151-6711","authenticated-orcid":false,"given":"Mohammad","family":"Alzoubi","sequence":"additional","affiliation":[{"name":"School of Medicine The University of Jordan  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0824-079X","authenticated-orcid":false,"given":"Jaleel J. 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