{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:18:20Z","timestamp":1789503500550,"version":"build-2803163510"},"reference-count":54,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To test the hypothesis that a link existed between vitamin D levels in the first trimester and gestational diabetes mellitus (GDM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The 25\u2010hydroxyvitamin D<jats:sub>3<\/jats:sub>levels were tested in the first trimester and pregnant outcomes were followed up in 1726 women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Only 5.9% of pregnant women have sufficient 25(OH)D<jats:sub>3<\/jats:sub>. More women with GDM are in the status of 25(OH)D<jats:sub>3<\/jats:sub>insufficiency than women with normal glucose tolerance (NGT) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Age (odds ratio [OR]: 1.047, 95% confidence interval [CI]: 1.014\u20131.081), pre\u2010pregnancy body mass index (BMI) (OR: 1.132, 95%CI: 1.092\u20131.173) were risk factors of GDM while 25\u2010(OH) D<jats:sub>3<\/jats:sub>(OR: 0.979, 95%CI: 0.960\u20130.999) was a protective factor. After adjusted for maternal age and pre\u2010pregnancy BMI, 25(OH)D<jats:sub>3<\/jats:sub>insufficiency (&lt;30\u2009ng\/mL) is an independent predictor of GDM (OR: 2.122, 95%CI: 1.084\u20134.155); 25(OH)D<jats:sub>3<\/jats:sub>level correlated with fasting blood glucose in the first trimester negatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Vitamin D insufficiency in early pregnancy was significantly associated with an increased risk for GDM in Chinese women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15333","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:04:13Z","timestamp":1657757053000},"page":"2353-2362","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Early pregnancy vitamin D insufficiency and gestational diabetes 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