{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T18:15:02Z","timestamp":1772820902568,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The number of babies born with Down syndrome has changed in recent years because of widespread availability of prenatal screening and advanced maternal age at delivery. In Japan, which has no public institutions that record data on babies born with chromosomal abnormalities (including Down syndrome), the accurate number remains unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Japan Association of Obstetricians and Gynecologists Birth Defects Monitoring Program (hereafter the JAOG Program) is the only national survey of congenital anomalies in Japan. Using data from this survey and vital statistics, we investigated the changes in the number of babies born with Down syndrome in Japan from 2006 to 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On performing linear regression analysis with the proportion of babies born with Down syndrome as the response variable, and the proportion of mothers giving birth at the age of 35\u2009years or older as the explanatory variable, the regression coefficient was 0.0054 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The proportion of mothers giving birth at the age of 35\u2009years or older was useful for predicting the proportion of babies born with Down syndrome. This proportion has increased since 2006 but has remained almost unchanged since 2015. In 2019, it was 1\/734.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study revealed that the proportion of mothers giving birth at the age of 35\u2009years or older strongly affected the proportion of babies born with Down syndrome. We assume that the proportion of babies is slightly affected by the increased number of pregnant women currently undergoing prenatal screening after the introduction of noninvasive prenatal genetic testing in 2013.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15342","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T07:34:42Z","timestamp":1656401682000},"page":"2385-2391","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Changes in the number of babies born with Down syndrome in Japan"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5801-0207","authenticated-orcid":false,"given":"Yoshinobu","family":"Sugo","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Yokohama City University Hospital Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2224-4455","authenticated-orcid":false,"given":"Kentaro","family":"Kurasawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yokohama City University Hospital Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Saigusa","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Yokohama City University Graduate School of Medicine Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruka","family":"Hamanoue","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yokohama City University Hospital Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiki","family":"Hirahara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yokohama City University Hospital Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5492-0844","authenticated-orcid":false,"given":"Etsuko","family":"Miyagi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yokohama City University Hospital Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960424)62:4<376::AID-AJMG10>3.0.CO;2-L"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0398-7620(05)84771-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32279"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5840"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4539"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13373"},{"key":"e_1_2_9_8_1","first-page":"101","article-title":"Current status of prenatal diagnosis in Japan 1998\u20132016","volume":"54","author":"Sasaki A","year":"2018","journal-title":"Nihon Shusanki\u2010Shinseiji Gakkai Zasshi"},{"key":"e_1_2_9_9_1","first-page":"1426","article-title":"Increasing share of pregnancies with advanced maternal age and its impact on the prevalence of Down syndrome","volume":"111","author":"Kajii T","year":"2007","journal-title":"Nihon Shounika Gakkai Zasshi"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32323"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1002\/ajmg.a.61298","article-title":"Equipoise of recent estimated down syndrome live births in Japan","volume":"179","author":"Sasaki A","year":"2019","journal-title":"Am J Med Genet"},{"key":"e_1_2_9_12_1","unstructured":"Official Statistics of Japan.e\u2010Stat: Portal site of Official Statistics for Japan. 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