{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T10:35:52Z","timestamp":1786703752786,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To explore whether sequential embryo transfer benefits patients with repeated implantation failure (RIF) undergoing frozen\u2013thawed embryo transfer (FET) cycles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 311 patients with a history of RIF in this retrospective study. We did sequential transfers with a cleavage embryo on day 3 and a blastocyst on day 5 in 77 patients; blastocyst transfers with two blastocysts on day 5 in 80 patients; and cleavage embryo transfers with two cleavage embryos on day 3 in 154 patients. We compared clinical outcomes between the three groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The clinical pregnancy rate was comparable between the blastocyst transfer group (48.8%), the sequential transfer group(48.1%) and the cleavage embryo transfer group (48.1%). There was no statistically significant difference found (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). The ongoing pregnancy and multipregnancy rates were also comparable between the three groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). The early miscarriage rate was significantly higher in the sequential transfer group (32.4%) compared with the blastocyst group (12.8%) and the cleavage embryo group (12.2%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). However, after adjusting for confounders, there was no significant difference in early miscarriage rates in the sequential transfer group compared with the blastocyst group (odds ratio [OR], 2.97; 95% confidence interval [CI], 0.85\u20139.24;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.07) and the cleavage embryo group (OR, 3.03; 95% CI, 0.94\u20138.06;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.08).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sequential embryo transfer failed to improve clinical outcomes for patients with RIF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.15369","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T20:34:00Z","timestamp":1658522040000},"page":"2563-2570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The outcomes of sequential embryo transfer in patients undergoing in vitro fertilization with frozen\u2013thawed embryos: A retrospective study"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9282-4415","authenticated-orcid":false,"given":"Mengxia","family":"Ji","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine, Department of Reproductive Endocrinology, Zhejiang Provincial People's Hospital Hangzhou Medical College  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Department of Reproductive Endocrinology, Zhejiang Provincial People's Hospital Hangzhou Medical College  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Fu","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Department of Reproductive Endocrinology, Zhejiang Provincial People's Hospital Hangzhou Medical College  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Xie","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Department of Reproductive Endocrinology, Zhejiang Provincial People's Hospital Hangzhou Medical College  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0853-8959","authenticated-orcid":false,"given":"Xiangli","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Department of Reproductive Endocrinology, Zhejiang Provincial People's Hospital Hangzhou Medical College  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shu","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Department of Reproductive Endocrinology, Zhejiang Provincial People's Hospital Hangzhou Medical College  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2017-03082"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)61781-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-81439-6"},{"key":"e_1_2_9_5_1","first-page":"9","article-title":"Diagnostic and therapeutic options in recurrent implantation failure","author":"Moustafa 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