{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T03:59:27Z","timestamp":1781236767133,"version":"3.54.1"},"reference-count":61,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>We aimed to investigate the effect of various vaginal wash solutions on reducing risks of post\u2010cesarean endometritis, wound infections, fever, and hospital stay duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Scopus, Web of Science, PubMed, and Cochrane Library were searched for randomized clinical trials that compared different vaginal wash solutions to each other or to \u201cno vaginal cleaning\u201d; without restriction on the age of parturients or site where trials were conducted. We analyzed this frequentist network meta\u2010analysis using the netmeta package in R software version 4.1.2; synthesized data as mean difference or risk ratio with their 95% confidence intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our network meta\u2010analysis included 29 RCTs with a total sample size of 9311 women undergoing CS. Regarding post\u2010cesarean endometritis, we found that povidone\u2010iodine had the highest significant risk reduction compared to \u201cno vaginal cleaning\u201d (RR\u00a0=\u00a00.08, 95% CI [0.01, 0.69]). While regarding post\u2010cesarean reduction of wound infection, fever, and hospital stay duration, we found that chlorhexidine 4% (RR\u00a0=\u00a00.17, 95% CI [0.05, 0.65]), saline 0.9% (RR\u00a0=\u00a00.12, 95% CI [0.03; 0.48]), and saline 0.9% (MD\u00a0=\u00a0\u22121.29, 95% CI [\u22122.18; \u22120.39]), respectively, had the highest significant risk reduction compared to \u201cno vaginal cleaning.\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Vaginal wash solutions were associated with a significant reduction of post\u2010cesarean endometritis, wound infection, fever, and hospital stay duration. Since povidone\u2010iodine had the highest significant reduction of post\u2010cesarean endometritis, we recommend setting povidone\u2010iodine as the standard practice as pre cesarean vaginal wash solution; consistent practice guidelines of Enhanced Recovery After Surgery (ERAS).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15377","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T09:30:01Z","timestamp":1659087001000},"page":"2659-2676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Vaginal preparation with different antiseptic solutions before cesarean section for preventing postoperative infections: A systematic review and network meta\u2010analysis"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5065-9626","authenticated-orcid":false,"given":"Hammad Ali","family":"Fadlalmola","sequence":"first","affiliation":[{"name":"Nursing College, 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