{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:09:37Z","timestamp":1790791777254,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Endometrial biopsy is generally performed with a metal uterine curette sonde; however, recently, many types of vacuum aspirators are available, including the manual vacuum aspiration (MVA) system. We used the women's MVA system for endometrial sampling and evaluated its effectiveness in determining the presence of endometrial malignancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010seven samples were examined using the following procedures after measuring endometrial thickness by transvaginal ultrasonography: fractional curettage biopsy (Bx; 20 samples), total curettage under general anesthesia (T\/C; 13 samples), and MVA (14 samples). The quality of the endometrial samples was classified into four types: 1\u20134, where 1 denoted poor and 4, good quality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean score of the MVA group was significantly higher than that of the partial curettage biopsy group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0065). No differences were observed between the MVA and total curettage groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a01.00). When patients were divided into two groups according to endometrial thickness (&lt;10\u2009mm or \u226510\u2009mm) and analyzed, both the MVA and T\/C groups did not show a significant difference in their scores compared to the Bx group when the endometrial thickness was &lt;10\u2009mm. However, when the endometrial thickness was \u226510\u2009mm, the MVA and T\/C groups had significantly better scores than the Bx group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0225 and <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0244, respectively). Vagal reflex, as an adverse event, was observed only in two patients in the Bx group (2\/20, 10%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Considering its quality and safety, Karman\u2010type MVA for endometrial sampling could be an alternative to fractional curettage using a metallic uterine curette sonde.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15403","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T08:49:23Z","timestamp":1661762963000},"page":"2896-2902","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Manual vacuum aspiration (women's <scp>MVA<\/scp>) for endometrial biopsy for patients with suspected endometrial malignancies"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9938-3758","authenticated-orcid":false,"given":"Etsuko","family":"Saito","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Tokyo Metropolitan Bokutoh Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tokyo Metropolitan Bokutoh Hospital  Tokyo Japan"},{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Nitta","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tokyo Metropolitan Bokutoh Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saho","family":"Fujino","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tokyo Metropolitan Bokutoh Hospital  Tokyo Japan"},{"name":"Department of Obstetrics National Center for Child Health and Development  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsushi","family":"Tsuruga","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayuyo","family":"Mori\u2010Uchino","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruko","family":"Iwase","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tokyo Metropolitan Bokutoh Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Kasamatsu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tokyo Metropolitan Bokutoh Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Kugu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tokyo Metropolitan Bokutoh Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Osuga","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,29]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Cancer Statistics.Cancer Information Service National Cancer Center Japan (National Cancer Registry Ministry of Health Labour and Welfare)[cited 1 Mar 2022] Available from:https:\/\/ganjoho.jp\/reg_stat\/statistics\/data\/dl\/index.html#a14"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.5152\/jtgga.2013.01"},{"key":"e_1_2_8_4_1","unstructured":"World Health Organization.Safe abortion: technical and policy guidance for health systems 2nd ed..Geneva:World Health Organization 2012."},{"key":"e_1_2_8_5_1","first-page":"140","article-title":"Diagnostic utility of endometrial aspiration cytology in women with abnormal uterine bleeding","volume":"9","author":"Handa U","year":"2018","journal-title":"J Midlife Health"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_291_20"},{"key":"e_1_2_8_7_1","unstructured":"Authorship.Women's MVA system for endometrial sampling[cited 3 Mar 2022]. Available from:https:\/\/www.womenshealthjapan.com\/dr\/product\/mva_system.html"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.108332"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2005.00324.x"},{"key":"e_1_2_8_10_1","first-page":"111","article-title":"Comparison of endometrial pathology between tissues obtained from manual vacuum aspiration and sharp metal curettage in women with abnormal uterine bleeding","volume":"99","author":"Sirimai K","year":"2016","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_8_11_1","first-page":"821","article-title":"Uterine perforation during curettage: perforation rates and postperforation management","volume":"16","author":"Ben\u2010Baruch G","year":"1980","journal-title":"Isr J Med Sci"},{"key":"e_1_2_8_12_1","first-page":"96","article-title":"Antepartum uterine rupture occurring at the site of a peviously repaired dilatation and curettage\u2010induced perforation: a case report","volume":"1","author":"Ghahramani L","year":"2013","journal-title":"Bull Emerg Trauma"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-3804(05)60207-1"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2014.09.032"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-020-01065-0"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2020.31.e51"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.15403","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.15403","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.15403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T17:36:26Z","timestamp":1692639386000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.15403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,29]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1111\/jog.15403"],"URL":"https:\/\/doi.org\/10.1111\/jog.15403","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,29]]},"assertion":[{"value":"2022-04-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}