{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:21:11Z","timestamp":1791591671136,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Lobular endocervical glandular hyperplasia (LEGH) is a multicystic proliferative disorder of the uterine cervix. The aim of this review was to clarify the current understanding of this unique tumor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This article reviews the chronological progress of research regarding clinico\u2010pathological and genetic aspects of LEGH and related cervical cystic diseases such as Nabothian cyst and adenocarcinoma of gastric type (GAS), using the literature and data from our institute. We also describe clinical management including preoperative diagnosis and adequate surgical\/expectant treatment based on the biological features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Recent studies revealed several unique aspects of LEGH, that is, (i) production of gastric mucin, (ii) symptomatic and histological similarity with minimal deviation adenocarcinoma (MDA), and (iii) frequent association with GAS, including MDA. These findings indicated that LEGH is a gastric metaplasia, as well as pre\u2010cancerous neoplasia. For the preoperative diagnosis of LEGH, the combination of \u201ccosmos\u201d sign on magnetic resonance imaging, detection of gastric mucin, and lack of nuclear atypia on cytology is important. Cone biopsy is effective for pathological diagnosis. Simple hysterectomy is indicated as surgical treatment for LEGH; however, meticulous follow\u2010up is also an option, especially for young patients, because the rate of malignant transformation was reported to be 1%\u20132%. For LEGH patients who selected follow\u2010up, a worsening cytology and increase in lesion size were important signs of malignant change of LEGH for safe follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Proper understanding of the characteristics of LEGH is important for adequate management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15441","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T08:46:02Z","timestamp":1664527562000},"page":"3056-3067","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Biology and management of lobular endocervical glandular hyperplasia"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1513-9473","authenticated-orcid":false,"given":"Tsutomu","family":"Miyamoto","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisanori","family":"Kobara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanri","family":"Shiozawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-46334-6"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-198302000-00005"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-198301000-00003"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199908000-00005"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-013-1417-1"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800148"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198909000-00001"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3180409"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199704000-00005"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19991025)87:5<245::AID-CNCR2>3.0.CO;2-0"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(01)00611-8"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200002000-00043"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2001.01239.x"},{"key":"e_1_2_10_15_1","first-page":"1287","article-title":"Preoperative differential diagnosis of minimal deviation adenocarcinoma and lobular endocervical glandular hyperplasia of the uterine cervix: a multicenter study of clinicopathology and magnetic resonance imaging findings","volume":"21","author":"Takatsu A","year":"2011","journal-title":"Int J Gynecol Cancer"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1999.5462"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds492"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181883722"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/019131299281347"},{"key":"e_1_2_10_20_1","volume-title":"WHO classification of tumours of female reproductive organs","author":"Kurman RJ","year":"2014"},{"key":"e_1_2_10_21_1","unstructured":"Adenocarcinoma HPV\u2010independent gastric type of the uterine cervix. Nabothian cyst p374\u20105 in WHO classification of tumours Editorial Board. Female genital tumors. Lyon (France): International Agency for Research on Cancer; 2020 (WHO classification of tumours series 5 th ed.; vol.4)."},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213434.91868.b0"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2019.01.022"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.5795\/jjscc.54.210"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000855"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02057.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2020-001612"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-018-1667-8"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49376-7"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099250"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59087"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-018-2469-z"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-019-02739-x"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2012.12.003"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.03.044"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2008.02.009"},{"key":"e_1_2_10_37_1","first-page":"2592","article-title":"Whole\u2010exome sequencing of lobular endocervical glandular hyperplasia","volume":"18","author":"Ida K","year":"2019","journal-title":"Oncol Lett"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.LAB.0000049821.16698.D0"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep00161"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(02)02294-8"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4012"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000093"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13083"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-020-00726-1"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2020.100571"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12538"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14602"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0221088"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.15441","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.15441","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.15441","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T06:06:05Z","timestamp":1705903565000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.15441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,30]]},"references-count":47,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1111\/jog.15441"],"URL":"https:\/\/doi.org\/10.1111\/jog.15441","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,30]]},"assertion":[{"value":"2022-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}