{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:35:36Z","timestamp":1747186536210,"version":"3.40.5"},"reference-count":49,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,10,2]],"date-time":"2022-10-02T00:00:00Z","timestamp":1664668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004621","name":"Kerman University of Medical Sciences","doi-asserted-by":"publisher","award":["98000762"],"award-info":[{"award-number":["98000762"]}],"id":[{"id":"10.13039\/501100004621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Vulvovaginal candidiasis (VVC), is a common fungal infection that remains a global concern. The objectives of this study were molecular identification and assessment of the antifungal susceptibility profile of <jats:italic>Candida<\/jats:italic> species, causing VVC in southeast Iran.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional investigation was carried out on 119 nonpregnant females suspected of VVC between February 2019 and May 2021. Yeast samples were characterized to the species level by conventional and molecular methods. All <jats:italic>Candida<\/jats:italic> isolates were examined for in vitro susceptibility profile to six conventional antifungal drugs using Clinical and Laboratory Standards Institute guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 119 subjects, 52 (43.7%) cases were affected by VVC, out of whom 11 (21.15%) cases had recurrent vulvovaginal candidiasis (RVVC). The species distribution was as follows; <jats:italic>Candida albicans<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a021; 40.4%), <jats:italic>C. glabrata<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a011; 21.2%), <jats:italic>C. tropicalis<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a09; 17.3%), <jats:italic>C. parapsilosis<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a05; 9.7%), <jats:italic>C. africana<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a03; 5.7%), <jats:italic>C. famata<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a01; 1.9%), <jats:italic>C. lusitaniae<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a01; 1.9%), and <jats:italic>C. dubliniensis<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a01; 1.9%). The resistance rate of <jats:italic>Candida<\/jats:italic> isolates to fluconazole, itraconazole, and voriconazole were 15.38%, 11.5%, and 3.8%, respectively. Resistance to fluconazole was obtained in 46% (5\/11) of RVVC cases but only in 7% (3\/41) of VVC cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrated that the majority of VVC cases were caused by non\u2010<jats:italic>albicans Candida<\/jats:italic> species which also were resistant to some antifungal agents. Hence, our findings revealed the importance of conducting periodical epidemiological studies to determine changes in species distribution. Moreover, for effective management of treatment and infection, it is imperative to evaluate the susceptibility profiles of <jats:italic>Candida<\/jats:italic> species isolated from VVC patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15442","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T02:20:07Z","timestamp":1664763607000},"page":"3292-3303","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Vulvovaginal candidiasis in Iranian women: Molecular identification and antifungal susceptibility pattern"],"prefix":"10.1111","volume":"48","author":[{"given":"Ali","family":"Khaksar Baniasadi","sequence":"first","affiliation":[{"name":"Student Research Committee, Afzalipour Faculty of Medicine Kerman University of Medical Sciences  Kerman Iran"},{"name":"Medical Mycology and Bacteriology Research Center Kerman University of Medical Sciences  Kerman 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