{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T02:18:00Z","timestamp":1787192280755,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T00:00:00Z","timestamp":1664064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005315","name":"Natural Science Foundation of Ningbo Municipality","doi-asserted-by":"publisher","award":["2018A610398"],"award-info":[{"award-number":["2018A610398"]}],"id":[{"id":"10.13039\/501100005315","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The potential effect of caffeine exposure during pregnancy on gestational hypertension (GH)\/preeclampsia has attracted attention but remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic literature search of PubMed, Embase, and Cochrane Library databases was performed until March 2022. Observational studies assessing the association between caffeine exposure during pregnancy and the risk of GH\/preeclampsia were included. The study protocol was registered in PROSPERO: CRD42022322387.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ten studies involving 114\u2009984 pregnant women (2548 diagnosed with GH and 2473 diagnosed with preeclampsia) were included. Comparing caffeine exposure with noncaffeine exposure, no significant association was found between caffeine exposure during pregnancy and the risk of GH (odds ratio [OR]\u00a0=\u00a00.99, 95% confidence interval [CI]: 0.90\u20131.08,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.800) and preeclampsia (OR\u00a0=\u00a01.13, 95% CI: 0.97\u20131.31,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.114). Subgroup analyses comparing low to moderate doses with no\/lowest doses showed that caffeine exposure during pregnancy was not significant associated with GH (OR\u00a0=\u00a01.00,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.987) or preeclampsia (OR\u00a0=\u00a01.03,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.648). Besides, subgroup analyses comparing high doses with no\/lowest doses showed that caffeine exposure during pregnancy was not significant associated with GH (OR\u00a0=\u00a01.06,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.623) or preeclampsia (OR\u00a0=\u00a01.18,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.192).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study found that caffeine exposure during pregnancy was not significantly associated with the risk of GH\/preeclampsia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.15445","type":"journal-article","created":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T21:49:48Z","timestamp":1664142588000},"page":"3045-3055","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The association between caffeine exposure during pregnancy and risk of gestational hypertension\/preeclampsia: A meta\u2010analysis and systematical review"],"prefix":"10.1111","volume":"48","author":[{"given":"Bangsheng","family":"Chen","sequence":"first","affiliation":[{"name":"Emergency Medical Center, Ningbo Yinzhou No. 2 Hospital  Ningbo Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengting","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical College Zhejiang Chinese Medical University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujing","family":"He","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical College Zhejiang Chinese Medical University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuexiu","family":"Si","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Zhejiang Chinese Medical University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yetan","family":"Shi","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical College Zhejiang Chinese Medical University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Jiang","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical College Zhejiang Chinese Medical University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Shen","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical College Zhejiang Chinese Medical University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaze","family":"Hong","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical College Zhejiang Chinese Medical University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2229-4594","authenticated-orcid":false,"given":"Saisai","family":"Ni","sequence":"additional","affiliation":[{"name":"Emergency Medical Center, Ningbo Yinzhou No. 2 Hospital  Ningbo Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003891"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-013-0395-8"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000437382.03963.88"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-020-01082-w"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32335-7"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17987-2"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000105"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2014.07.003"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2019.11.004"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2903\/sp.efsa.2013.EN-394"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10111772"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2010.01561.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j5024"},{"key":"e_1_2_10_15_1","unstructured":"WHO Guidelines Approved by the Guidelines Review Committee.WHO Recommendations on Antenatal Care for a Positive Pregnancy Experience. 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