{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T14:44:45Z","timestamp":1776177885406,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,2]],"date-time":"2022-10-02T00:00:00Z","timestamp":1664668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the success of local methotrexate (MTX) treatment, the side\u2010effect profile and its fertility effect in patients diagnosed with cesarean scar pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials<\/jats:title><jats:p>This retrospective cohort study included 56 cesarean scar pregnancy patients who applied to Erciyes University Faculty of Medicine, Department of Obstetrics and Gynecology between January 2012 and January 2022 and were treated with ultrasound\u2010guided local MTX. The results of 56 patients with cesarean scar pregnancy who underwent transvaginal ultrasound\u2010guided single\u2010dose local MTX treatment were evaluated. First, the contents of the sac were aspirated, and then 50\u2009mg of MTX was injected into the gestational sac.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median gestational age at diagnosis was 7\u2009weeks 2\u2009days. The mean beta human chorionic gonadotrophin level was 31\u2009345\u2009\u00b1\u200937\u2009838 (range: 113\u2013233\u2009835\u2009mIU\/mL). Fifty\u2010four patients were successfully treated with local MTX therapy. The interval between the first MTX injection and the normalization of beta human chorionic gonadotrophin was 55.2\u2009\u00b1\u200941.0\u2009days. None of our patients required surgical treatment. Beta human chorionic gonadotrophin values did not decrease in one patient and she was treated with systemic MTX. Local MTX therapy could not be applied to one patient for technical reasons. Only one patient needed blood transfusion after local MTX. Thirteen patients become pregnant after treatment (76%). No systemic side effects related to MTX were observed in any of the patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Transvaginal ultrasound\u2010guided single\u2010dose local MTX treatment is an effective, safe, and fertility\u2010preserving treatment method for cesarean scar pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15453","type":"journal-article","created":{"date-parts":[[2022,10,2]],"date-time":"2022-10-02T23:11:20Z","timestamp":1664752280000},"page":"122-127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Is local methotrexate therapy effective in the treatment of cesarean scar pregnancy? A retrospective cohort study"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6492-3379","authenticated-orcid":false,"given":"Fulya","family":"Cagli","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Erciyes University  Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Dolanbay","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Erciyes University  Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varol","family":"G\u00fclseren","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Erciyes University  Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serhan","family":"K\u00fct\u00fck","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Develi Public Hospital  Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ercan M.","family":"Aygen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Erciyes University  Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.125998"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.974"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1224874"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2013.06.029"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-014-3206-8"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13256"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.12.130"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12414"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2019.07.010"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2021.11.008"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.04.018"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.56"},{"key":"e_1_2_8_14_1","first-page":"371","article-title":"Unforeseen consequences of the increasing rate of cesarean deliveries: early placenta accrete and cesarean scar pregnancy. A review","volume":"210","author":"Timor\u2010Tritsch IE","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(97)81930-9"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-013-2765-4"},{"key":"e_1_2_8_17_1","first-page":"15","article-title":"Outcome of cesarean scar pregnancy treated with local methotrexate injection","volume":"82","author":"Tam LM","year":"2020","journal-title":"Nagoya J Med Sci"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2015.04.008"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.2018.61.1.147"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2019.10.036"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.15453","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.15453","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.15453","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T23:33:26Z","timestamp":1692228806000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.15453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,2]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/jog.15453"],"URL":"https:\/\/doi.org\/10.1111\/jog.15453","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,2]]},"assertion":[{"value":"2022-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}