{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:35:37Z","timestamp":1747186537474,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,2]],"date-time":"2022-10-02T00:00:00Z","timestamp":1664668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010804","name":"Faculty of Medicine, Prince of Songkla University","doi-asserted-by":"publisher","award":["58\u2010343\u201012\u20104"],"award-info":[{"award-number":["58\u2010343\u201012\u20104"]}],"id":[{"id":"10.13039\/501100010804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to study serum beta\u2010human chorionic gonadotropin level trends after medical abortion using mifepristone and misoprostol in the early first trimester.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled women at \u226463\u2009days of gestation who were indicated for pregnancy termination. We excluded women with incomplete abortions, nonviable pregnancies, extrauterine pregnancies, and contraindications for mifepristone\/misoprostol use. Women received oral mifepristone (200\u2009mg), followed by vaginal misoprostol (800 mcg) after 48\u2009h. Serum beta\u2010human chorionic gonadotropin levels were monitored pre\u2010mifepristone administration (day 1); 48\u2009h post\u2010mifepristone, pre\u2010misoprostol administration (day 3); day 10; and weekly after day 10, until negative beta\u2010human chorionic gonadotropin levels (&lt;25 mIU\/mL) were achieved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 39 enrolled women, 36 (92.3%) who underwent complete abortion without further interventions were included. The median gestational age was 51 (32\u201361) days. Three phases of beta\u2010human chorionic gonadotropin levels were observed: an increase of up to 5.1% within 48\u2009h of taking mifepristone, before misoprostol administration; a rapid decline on day 10 (by 98.5% compared with initial levels); and a slow decline after day 10 until negative results were attained within 7\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum beta\u2010human chorionic gonadotropin levels minimally increased 48\u2009h after taking mifepristone, rapidly declined within 1\u2009week of misoprostol administration, and slowly declined until negative within 7\u2009weeks post\u2010abortion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15455","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T02:19:37Z","timestamp":1664763577000},"page":"103-108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Trend of serum beta\u2010human chorionic gonadotropin levels after medical abortion in the early first trimester of pregnancy"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8618-0609","authenticated-orcid":false,"given":"Thanapan","family":"Choobun","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Prince of Songkla University  Hat Yai Songkhla Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronnarong","family":"Maneeon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Prince of Songkla University  Hat Yai Songkhla Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02636.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31818d8eb4"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/13.10.2962"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(03)00012-5"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/13625180701536300"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003303421307"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2010.07.023"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(79)90383-1"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2009.08.008"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2016.09.007"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2015.03.004"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.9.2315"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(01)00266-9"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000142712.80407.fd"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(01)00228-1"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2004.04.005"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-018-1804-3"}],"container-title":["Journal 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