{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:20:50Z","timestamp":1791303650605,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to compare maternal blood and umbilical\u2010cord leptin, spexin and visfatin levels during delivery in severe preeclampsia (PE) with controls, and to evaluate whether any clinical or demographic variables had independent associations with them.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a case\u2010controlled observational study consisting of 45 pregnant women with severe PE and a control group consisting of gestational age\u2010matched 45 healthy pregnant women. We examined the leptin, spexin, and visfatin levels in serum samples taken from maternal blood and umbilical cords during cesarean section in both groups. Leptin, spexin, and visfatin levels were measured by enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The maternal leptin and visfatin levels were significantly higher and the maternal spexin levels were significantly lower in the PE group than in the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Similar to the maternal adipokine levels, the umbilical\u2010cord leptin and visfatin levels were significantly higher and the spexin levels were significantly lower in the PE group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). We found a significant positive correlation between maternal body mass index and maternal blood and umbilical\u2010cord serum leptin and visfatin levels in both groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The leptin, spexin and visfatin levels were significantly altered in the nondiabetic preeclamptic women in our study. We believe that the main reason for these changes may be the hypoxic placenta to protect the fetus and maintain its nutrition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15463","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T11:55:17Z","timestamp":1665662117000},"page":"154-163","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of the adipokine levels of pregnant women with preeclampsia"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8940-1879","authenticated-orcid":false,"given":"Soner","family":"G\u00f6k","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Pamukkale University Hospital Denizli Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5739-3683","authenticated-orcid":false,"given":"Berfin 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