{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T03:12:55Z","timestamp":1784949175921,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Preeclampsia (PE) is a common medical complication of pregnancy characterized by high blood pressure and proteinuria after the 20th gestational week. This study aimed to investigate the potency of the combination of curcumin and aspirin in the treatment of PE and explore the underlying mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>The PE model was constructed in female rats by administering 0.5\u00a0mg\/mL N\u2010nitro\u2010L\u2010arginine methyl ester from gestational days (GDs) 6 to 16. The pregnant female rats were divided into five groups according to the drug treatment. The curcumin or aspirin was given to the rats by tail vein injection (0.36\u2009mg\/kg) or gavage treatment (1.5\u00a0mg\/kg BW\/day) from GD4 to GD18.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment with curcumin and aspirin combination significantly reduced the systolic blood pressure and proteinuria in the PE rats. Meanwhile, in comparison to the PE rats treated with single\u2010dose curcumin or aspirin, the rats treated with combined curcumin and aspirin showed significantly decreased sFlt\u20101, increased placental growth factor, and alleviated oxidative stress in both blood and placental tissues, which are abnormal in no\u2010treated PE rats. Furthermore, dramatically decreased inflammatory cytokines secretion and TLR4 and NF\u2010\u03baB p65 expression in placental tissues were also observed in the PE rats with combined treatment compared to those of no\u2010treated, signal\u2010dose curcumin or aspirin\u2010treated PE rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggested that the combined treatment of curcumin and aspirin significantly ameliorates the symptoms of PE in rats, which is most likely due to the inhibition of the placental TLR4\/NF\u2010\u03baB p65 signaling pathway.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15473","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:58:56Z","timestamp":1666832336000},"page":"128-140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Combining curcumin and aspirin ameliorates preeclampsia\u2010like symptoms by inhibiting the placental <scp>TLR4<\/scp>\/<scp>NF\u2010\u03baB<\/scp> signaling pathway in rats"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5716-5290","authenticated-orcid":false,"given":"Yaru","family":"Ju","sequence":"first","affiliation":[{"name":"Perinatal Center The Fourth Hospital of Shijiazhuang  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Second Hospital of Hebei Medical University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjing","family":"Yang","sequence":"additional","affiliation":[{"name":"Perinatal Center The Fourth Hospital of Shijiazhuang  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Hou","sequence":"additional","affiliation":[{"name":"Prenatal Diagnostic The Fourth Hospital of Shijiazhuang  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