{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:40:46Z","timestamp":1777336846248,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>An increasing number of infants are being conceived using assisted reproductive technology (ART). The effects of infertility treatments (IFTs) on infant outcomes have been extensively debated; however, a consensus has not yet been reached. In the present study, we investigated the impact of IFTs on neonatal intensive care unit (NICU) managements using data collected at a single large NICU center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively investigated patients admitted to the University of Tokyo Hospital NICU during three different time periods (2010, 2015, and 2020). We included 131, 201, and 323 infants, respectively, and compared a number of factors among groups classified by the mode of conception: spontaneous pregnancy (SP), non\u2010ART (conceived with assisted ovulation or artificial insemination), and ART. We also compared the mode of conception among inborn singletons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The rate of admission of ART infants significantly increased from 2010 (9.1%) to 2015 (22.9%) and 2020 (25.7%) (<jats:italic>p<\/jats:italic> values of &lt;0.05 and &lt;0.01, respectively). When compared among inborn singletons, ART infants were more often admitted to NICU (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Congenital anomalies and surgical interventions were significantly more frequent in the SP group than in the ART group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). No significant differences were observed in neonatal outcomes among ART infants from 2010 to 2015\/2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The rate of ART infants admitted to the NICU has significantly increased, with ART pregnancies now accounting for 25% of admissions to the perinatal medical center. ART procedure may be a risk factor for NICU admission. Neonatal intensive care is becoming increasingly indispensable for ART pregnancies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15478","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T22:23:10Z","timestamp":1666736590000},"page":"273-279","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assisted reproductive technology and neonatal intensive care unit: A retrospective observational study from a single center"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2258-054X","authenticated-orcid":false,"given":"Kyosuke","family":"Ibi","sequence":"first","affiliation":[{"name":"Department of Pediatrics The University of Tokyo Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The University of Tokyo Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92957-4"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep098"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2208"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1488168"},{"key":"e_1_2_8_6_1","first-page":"2110","article-title":"Summary report of ART online registry for 2010 by the Ethics Committee of the Japan Society of Obstetrics and Gynecology","volume":"64","author":"Saito H","year":"2012","journal-title":"Acta Obstet Gynecol Jpn"},{"key":"e_1_2_8_7_1","first-page":"1089","article-title":"Summary report of ART online registry for 2019 by the Ethics Committee of the Japan Society of Obstetrics and Gynecology","volume":"73","author":"Katagiri Y","year":"2021","journal-title":"Acta Obstet Gynecol Jpn"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15437"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.01.015"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.12.095"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmt006"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719118756750"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.12.031"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2014.01.001"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e32832924a7"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-26567-2"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.97.5.688"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.8.2089"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38919.495718.AE"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-044385"},{"key":"e_1_2_8_21_1","first-page":"1271","article-title":"Committee of Neonatal Medicine of Japan pediatric society. 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