{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:35:42Z","timestamp":1747186542892,"version":"3.40.5"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,20]],"date-time":"2022-11-20T00:00:00Z","timestamp":1668902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>B\u2010mode ultrasonography utilized for fetal screening of common trisomies is referred to as a genetic sonogram and includes determining major abnormalities and soft markers such as hypoplastic nasal bone and increased thickness of the nuchal fold. Elastography is a novel ultrasound technique giving information about tissue stiffness used for diagnosing cancer, transplant rejection, and organ fibrosis. This study aimed to determine via shear wave elastography (SWE) whether euploid and aneuploid fetal soft marker tissues vary in stiffness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The participants were all singleton pregnancies between 19 and 23\u2009weeks of gestation; 35 euploid and 14 aneuploid fetus pregnancies were enrolled. Fetal bowel, kidney, liver, nasal bone, nuchal fold, placenta, and myometrium were investigated with SWE using acoustic radiation impulse force. Images were analyzed with a novel software calibrated and written by us using MATLAB. Statistical analysis was completed with the SPSS Program. Shapiro\u2013Wilk normality distribution analysis, Student's <jats:italic>t<\/jats:italic>\u2010test, and Mann\u2013Whitney <jats:italic>U<\/jats:italic> methods were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean shear wave speed of fetal nasal bone was significantly lower in aneuploid fetuses. There was no difference between other tissues in mean shear wave velocity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Euploid and aneuploid fetuses have different elastic properties of the nasal bone and this may have a role in differentiating aneuploid fetuses noninvasively.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15483","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T02:16:18Z","timestamp":1668996978000},"page":"568-576","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of fetal and maternal tissue elasticity between euploid and aneuploid pregnancies by shear wave elastography"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2755-3700","authenticated-orcid":false,"given":"Gokce Naz","family":"Kucukbas","sequence":"first","affiliation":[{"name":"Kocaeli Derince Training and Research Hospital, Department of Obstetrics and Gynecology, Perinatology Division Karadenizliler Mahallesi \u0130zmit Kad\u0131n Do\u011fum ve \u00c7ocuk Hastanesi  \u0130zmit\/Kocaeli Turkey"},{"name":"Perinatology Division, Department of Obstetrics and Gynecology Van Yuzuncu Yil University  Van Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah Ruhi","family":"Soylu","sequence":"additional","affiliation":[{"name":"Department of Biophysics Hacettepe University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14569"},{"issue":"1","key":"e_1_2_8_3_1","first-page":"15","article-title":"Trisomy 13, 18, 21, Triploidy and turner syndrome: the 5T's. 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