{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T14:55:26Z","timestamp":1775055326037,"version":"3.50.1"},"reference-count":62,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T00:00:00Z","timestamp":1670630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD086805"],"award-info":[{"award-number":["R01HD086805"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Chronic <jats:italic>Toxoplasma gondii<\/jats:italic> infection is not thought to affect pregnancy or birth outcomes, but there are few prospective studies. The study aims were <jats:italic>T. gondii<\/jats:italic> immunoglobulin G measurement and relationship of chronic <jats:italic>T. gondii<\/jats:italic> infection with gestational age at birth and adverse pregnancy outcomes in 690 Hispanic women in Tampa, Florida.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Hispanic women, born either in the United States or in Latin America or the Caribbean had a venous blood sample drawn to measure <jats:italic>T. gondii<\/jats:italic> IgG and <jats:italic>T. gondii<\/jats:italic> serotype at the first prenatal visit, along with collection of demographic and health\u2010related measures. Seropositive and seronegative women were followed throughout their pregnancy. Gestational age, infant weights, and adverse pregnancy outcomes (miscarriages, preterm births) were compared in the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 740 women of self\u2010reported Hispanic ethnicity screened and enrolled in Tampa, Florida, with 690 having birth data extracted from the electronic health record (538\u2009<jats:italic>T. gondii<\/jats:italic> negative and 152\u2009<jats:italic>T. gondii<\/jats:italic> seropositive). <jats:italic>T. gondii<\/jats:italic> seropositivity was 22.4% and the majority (83%) had high avidity titers, indicating chronic infection. Compared to <jats:italic>T. gondii<\/jats:italic> seronegative Hispanic women, seroseropositive women had more smaller for gestational age infants and higher prevalences of miscarriages and preterm birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is one of the largest longitudinal cohort studies of women with chronic <jats:italic>T. gondii<\/jats:italic> infection followed through pregnancy. There was a higher percentages of adverse pregnancy outcomes in this group compared to <jats:italic>T. gondii<\/jats:italic> seronegative controls. The mechanism for this is unknown and warrants reexamination of the dogma that chronic <jats:italic>T. gondii<\/jats:italic> infection in pregnant women has no significant clinical consequences.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15511","type":"journal-article","created":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T12:34:07Z","timestamp":1670675647000},"page":"893-903","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Adverse pregnancy outcomes in <scp><i>Toxoplasma gondii<\/i><\/scp> seropositive Hispanic women"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8047-6997","authenticated-orcid":false,"given":"Tina","family":"Mutka","sequence":"first","affiliation":[{"name":"University of South Florida College of Nursing  Tampa Florida 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