{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T13:33:52Z","timestamp":1775914432696,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T00:00:00Z","timestamp":1672876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>To investigate whether the SERPINC1, E\u2010selectin, P\u2010selectin, and RBP4 levels in first trimester maternal serum was associated with the presence of preeclampsia (PE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study was conducted on 26 women with early\u2010onset preeclampsia (EO\u2010PE), 27 women with late\u2010onset preeclampsia (LO\u2010PE), and 27 women with uncomplicated pregnancies. Levels of serum SERPINC1, E\u2010selectin, P\u2010selectin, and RBP4 were measured with the use of an enzyme\u2010linked immunosorbent assay (ELISA) kit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>E\u2010Selectin levels in patients with EO\u2010PE were higher than those with LO\u2010PE and control patients (<jats:italic>p<\/jats:italic><jats:sub>E\u2010L<\/jats:sub>\u00a0=\u00a00.025; <jats:italic>p<\/jats:italic><jats:sub>E\u2010C<\/jats:sub>\u00a0=\u00a00.000; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). There was no significant intergroup difference in terms of P\u2010selectin and RBP4 levels (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). SERPINC1 levels were lower in the patients in the with EO\u2010PE group than in those in the LO\u2010PE and the control groups (<jats:italic>p<\/jats:italic><jats:sub>E\u2010L<\/jats:sub>\u00a0=\u00a00.000; <jats:italic>p<\/jats:italic><jats:sub>E\u2010C<\/jats:sub>\u00a0=\u00a00.000; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In the PE group, there was a negative, moderate (41.7%) correlation between E\u2010selectin level and SERPINC1 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.002; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The receiver operating characteristic (ROC) curve showed that the best cut\u2010off values for E\u2010selectin were 23.14\u2009ng\/ml\u2009&gt;\u2009with 100% sensitivity and 100% specificity. The ROC curve showed that the best cut\u2010off values for SERPINC1 were \u226487.76\u2009ng\/ml with 98.1% sensitivity and 96.3% specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Of the endothelial damage parameters, E\u2010selectin and SERPINC1 are especially associated with EO\u2010PE. Furthermore, they can be used as potential early diagnosis markers in the prediction of PE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15532","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T05:35:40Z","timestamp":1672983340000},"page":"870-882","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Assessment of maternal serum <scp>SERPINC1<\/scp>, <scp>E<\/scp>\u2010selectin, <scp>P<\/scp>\u2010selectin, and <scp>RBP4<\/scp> levels in pregnancies with early\u2010 and late\u2010onset preeclampsia"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2717-7925","authenticated-orcid":false,"given":"Rabia Merve","family":"Palal\u0131o\u011flu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Health Sciences Umraniye Training and Research Hospital  Istanbul 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