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At 33\u2009years, whole\u2010exome sequencing revealed a homozygous nonsense variant (c.1894C\u2009&gt;\u2009T:p.Arg632*) in <jats:italic>AEBP1<\/jats:italic>. This is the 10th case of <jats:italic>AEBP1<\/jats:italic>\u2010related EDS (classical\u2010like EDS type 2) and the first in Japan. She was managed as an inpatient at our hospital beginning at 20\u2009weeks of gestation because of the possibility of high\u2010risk pregnancy. She experienced painful urinary retention, migraines, and threatened premature labor. She delivered a healthy female via elective caesarean section at 32\u2009weeks of gestation. She was treated in the intensive care unit for severe paralytic ileus, postoperatively. Conservative therapy resulted in favorable outcomes, and she was safely discharged on postdelivery day 22nd.<\/jats:p>","DOI":"10.1111\/jog.15541","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T04:56:20Z","timestamp":1672894580000},"page":"1043-1047","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The detailed obstetric course of the first Japanese patient with <scp><i>AEBP1<\/i><\/scp>\u2010related <scp>Ehlers\u2013Danlos<\/scp> syndrome (classical\u2010like <scp>EDS<\/scp>, type 2)"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6681-702X","authenticated-orcid":false,"given":"Hiromi","family":"Sanai","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Yamaguchi Prefectural Grand Medical Center  Hofu Yamaguchi Japan"},{"name":"Department of Medical Genetics Yamaguchi Prefectural Grand Medical Center  Hofu Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yamaguchi Prefectural Grand Medical Center  Hofu Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Koike","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Nagasaki University Hospital  Nagasaki Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Murota","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Nagasaki University Hospital  Nagasaki Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Kosho","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Shinshu University Hospital  Matsumoto Nagano Japan"},{"name":"Center for Medical Genetics Shinshu University Hospital  Matsumoto Nagano Japan"},{"name":"Division of Clinical Sequencing Shinshu University School of Medicine  Matsumoto Nagano Japan"},{"name":"Research Center for Supports to Advanced Science Shinshu University  Matsumoto Nagano Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakatsu","family":"Sase","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yamaguchi Prefectural Grand Medical Center  Hofu Yamaguchi Japan"},{"name":"Department of Medical Genetics Yamaguchi Prefectural Grand Medical Center  Hofu Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0194-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2020.1767574"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31552"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2020.10.033"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-016-1660-z"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddz024"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.02.018"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.60679"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes10020135"},{"key":"e_1_2_7_11_1","unstructured":"gnomAD. 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