{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T03:13:18Z","timestamp":1767237198267,"version":"3.40.5"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004847","name":"Zahedan University of Medical Sciences","doi-asserted-by":"publisher","award":["grant no. 9895"],"award-info":[{"award-number":["grant no. 9895"]}],"id":[{"id":"10.13039\/501100004847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chromodomain\u2010helicase 5 (<jats:italic>CHD5<\/jats:italic>) is a conventional tumor\u2010suppressing gene in many tumors. The <jats:italic>CHD5<\/jats:italic> gene, as a key factor in the chromatin density process during sperm maturation, can affect the risk of infertility. This study aimed to determine whether CHD5 variants contribute to the risk of male infertility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Gene variants were identified using tetra primer\u2010ARMS\u2010PCR method on nonobstructive azoospermia and severe oligozoospermia in a case\u2013control study. SPSS software 20 (SPSS Inc. Chicago, IL, USA) was used for data recording and statistical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the codominant pattern, the rs12067480 TT variant versus CC significantly increased the risk of disease, and also, in the recessive pattern, TT variant versus CC\u2009+\u2009CT and T allele versus C. The rs2273032 variant was associated with the risk of infertility in codominant pattern AA versus GG and recessive pattern AA versus GG\u2009+\u2009GA and allele. We discovered that the rs12067480 T and rs2273032 A alleles increase the risk of male infertility. Also, the interaction of the CT\/GA, CT\/AA, TT\/GA genotypes and rs12067480T\/rs2273032A and rs12067480T\/rs2273032G haplotypes significantly increased the risk of infertility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that the <jats:italic>CHD5<\/jats:italic> gene polymorphisms contribute to the risk of male infertility. Our findings can be valuable in improving the diagnosis and treatment of infertility.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15560","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T11:44:56Z","timestamp":1674647096000},"page":"1214-1221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The possible impact of <scp>DNA<\/scp>\u2010binding chromodomain\u2010helicase 5 polymorphisms on male infertility: A case\u2013control study"],"prefix":"10.1111","volume":"49","author":[{"given":"Bita","family":"Moudi","sequence":"first","affiliation":[{"name":"Infectious Diseases and Tropical Medicine Research Center Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Medical Sciences  Zahedan Iran"},{"name":"Department of Histology, School of Medicine Zahedan University of Medical Sciences  Zahedan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azam","family":"Asemi\u2010Rad","sequence":"additional","affiliation":[{"name":"Department of Anatomical Sciences School of Medicine, Zahedan University of Medical Sciences  Zahedan Iran"},{"name":"Cellular and Molecular Research Center Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Medical Sciences  Zahedan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Sheibak","sequence":"additional","affiliation":[{"name":"Department of Histology, School of Medicine Zahedan University of Medical Sciences  Zahedan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3401-1619","authenticated-orcid":false,"given":"Zahra","family":"Heidari","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Tropical Medicine Research Center Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Medical Sciences  Zahedan Iran"},{"name":"Department of Histology, School of Medicine Zahedan University of Medical Sciences  Zahedan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3732-2586","authenticated-orcid":false,"given":"Hamidreza","family":"Mahmoudzadeh\u2010Sagheb","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Tropical Medicine Research Center Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Medical Sciences  Zahedan Iran"},{"name":"Department of Histology, School of Medicine Zahedan University of Medical Sciences  Zahedan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.01.165"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2015.12.020"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2223-4683.2014.02.06"},{"key":"e_1_2_10_5_1","unstructured":"WeinAJ KL NovickAC PartinAW PetersCA.Campbel\u2013Walsh Urology 10th Edition Philadelphia: W 2010: 25\u201330."},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.1985.tb00839.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-038-0_27"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mefs.2010.06.002"},{"key":"e_1_2_10_9_1","first-page":"1","article-title":"Male idiopathic infertility and the TP53 polymorphism in codon 72","volume":"5","author":"Morais M","year":"2016","journal-title":"Genet Mol Res"},{"key":"e_1_2_10_10_1","first-page":"3066","volume-title":"Human reproduction","author":"Ezeh U","year":"1998"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7262.2008.00295.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206211"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.11.052"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/03000605221105344"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600703"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2013.10.005"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn176"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.05.003"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28316"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23812"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4551-y"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.08.013"},{"key":"e_1_2_10_23_1","first-page":"1","article-title":"The potential impact of tumor suppressor genes on human gametogenesis: a case\u2010control study","volume":"37","author":"Hershlag A","year":"2019","journal-title":"J Assist Reprod Genet"},{"key":"e_1_2_10_24_1","first-page":"854","volume-title":"Human reproduction","author":"Enginsu ME","year":"1991"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/1348-0421.12382"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14688"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.5812\/hepatmon.34266"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.5935\/1518-0557.20210025"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-018-0003-3"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.XHA.0000397686.82729.09"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.20471\/acc.2019.58.03.15"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10223.x"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23791"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.12.009"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.10.045"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4812"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202559"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddaa101"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.15560","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.15560","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.15560","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T15:22:00Z","timestamp":1692544920000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.15560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,25]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/jog.15560"],"URL":"https:\/\/doi.org\/10.1111\/jog.15560","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"type":"print","value":"1341-8076"},{"type":"electronic","value":"1447-0756"}],"subject":[],"published":{"date-parts":[[2023,1,25]]},"assertion":[{"value":"2022-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}