{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T03:59:39Z","timestamp":1793246379313,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004256","name":"Razi University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005317","name":"Kermanshah University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005317","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The present study aimed to explore the potential ameliorative effects of L\u2010arginine (LA), L\u2010carnitine (LC), and bone marrow mesenchymal stem cell\u2010conditioned medium (BMSC\u2010CM) on endometriosis (EMS) model in vivo and in vitro.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The animals were divided into two main groups, normal and EMS\u2010induced mice. Normal and EMS\u2010induced groups were injected with or without LA (250\u2009mg\/kg), LC (250\u2009mg\/kg), and BMSC\u2010CM (a final volume of 100\u2009\u03bcL of CM\/mouse). At the end of the study, the level of total antioxidant capacity (TAC), nitric oxide (NO), and total oxidative status (TOS) were measured in plasma. Furthermore, immature oocytes were collected from two groups and cultured in a maturation medium. Subsequently, the rates of in vitro maturation, in vitro fertilization (IVF), and in vitro embryonic development were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The results revealed that administration of LA, LC, and BMSC\u2010CM ameliorated the oxidative status through maintaining TAC and alleviating TOS and NO levels. More importantly, the maturation and fertilization rates, blastocyst development, and total blastocyst cell numbers significantly increased in LA, LC, and BMSC\u2010CM\u2010administrated groups compared to the control group. In both the normal and EMS groups, the highest IVF, cleavage, and blastocyst percentages were associated with BMSC\u2010CM treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Altogether, LA, LC, and BMSC\u2010CM have therapeutic effects on impaired oocyte quality and promote subsequent development in vitro, probably through normalization of nitro\u2010oxidative stress, thus offering potential alternatives to conventional therapies during assisted reproductive technologies for patients with EMS\u2010associated sub\/infertility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.15569","type":"journal-article","created":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T01:04:15Z","timestamp":1675472655000},"page":"1180-1188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Therapeutic effects of\n                    <scp>L\u2010arginine<\/scp>\n                    ,\n                    <scp>L\u2010carnitine<\/scp>\n                    , and mesenchymal stem\n                    <scp>cell\u2010conditioned<\/scp>\n                    medium on endometriosis\u2010induced oocyte poor quality in an experimental mouse model"],"prefix":"10.1111","volume":"49","author":[{"given":"Eshrat","family":"Kalehoei","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Basic Sciences Razi University  Kermanshah 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