{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T15:43:42Z","timestamp":1763480622433,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T00:00:00Z","timestamp":1676246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare the clinical outcomes among women diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection during pregnancy, and their neonates, during the period when the Omicron variant predominated in Japan with those of the pre\u2010Omicron variant period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective single\u2010center cohort study between August 1, 2020, and June 30, 2022. The cohort was divided into pre\u2010Omicron group (August 1, 2020 to November 30, 2021) and Omicron group (December 1, 2021 to June 30, 2022). The primary outcome was maternal intensive care unit (ICU) admission during the perinatal period. The secondary outcomes were maternal oxygen administration before and after delivery, preterm birth (PTB), and low birth weight (LBW).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study period, 81 pregnant women were admitted to the hospital with SARS\u2010CoV\u20102 infection (pre\u2010Omicron period, <jats:italic>n<\/jats:italic>\u00a0=\u00a028; Omicron period, <jats:italic>n<\/jats:italic>\u00a0=\u00a053). SARS\u2010CoV\u20102 infection during the Omicron period was associated with lower risk of maternal ICU admission (adjusted\u2010odds ratio [aOR]: 0.10, 95% confidence interval [CI]: 0.01\u20131.23, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.072), oxygen administration via a nasal cannula or mask (aOR: 0.18, 95% CI: 0.03\u20130.96, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.045), PTB (aOR: 0.15, 95% CI: 0.04\u20130.51, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002), and LBW (aOR: 0.13, 95% CI: 0.03\u20130.55, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among pregnant women, SARS\u2010CoV\u20102 infection during the Omicron period was associated with reduced risk of maternal ICU admission, requiring supplemental oxygen, PTB, and LBW. This can be attributable to lower virulence of the Omicron variant and higher vaccination coverage during the Omicron period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15610","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:27:15Z","timestamp":1676334435000},"page":"1348-1354","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Severity of SARS\u2010CoV\u20102 infection in pregnant women and their neonates during the Omicron period compared to the pre\u2010Omicron period: A retrospective cohort study"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8233-9144","authenticated-orcid":false,"given":"Takumi","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"Department of Anesthesia and Intensive Care Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital  Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuto","family":"Makino","sequence":"additional","affiliation":[{"name":"Department of Preventive Services Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Mabuchi","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital  Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keito","family":"Okuda","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital  Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroe","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital  Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital  Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital  Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Hirate","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital  Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,13]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization. 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