{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T04:23:16Z","timestamp":1787631796263,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,4]],"date-time":"2023-03-04T00:00:00Z","timestamp":1677888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20fk0108143"],"award-info":[{"award-number":["JP20fk0108143"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to clarify the diagnostic accuracy of amniotic fluid interleukin\u20106 for fetal inflammatory response syndrome (FIRS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study was conducted in a single institution and targeted cases of preterm birth within 24\u2009h after amniocentesis among singleton cases that underwent amniocentesis at our hospital for suspected intraamniotic inflammation (IAI) from gestational ages of 22\u201336\u2009weeks between August 2014 and March 2020. FIRS was defined as &gt;11.0\u00a0pg\/mL of umbilical cord blood interleukin\u20106.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis included 158 pregnant women. There was a strong correlation between amniotic fluid interleukin\u20106 and umbilical cord blood interleukin\u20106 (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.70, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The area under the receiver operating characteristic curve of amniotic fluid interleukin\u20106 for FIRS was 0.93, with a cutoff value of 15.5\u00a0ng\/mL, and showed high sensitivity and specificity (0.91 and 0.88, respectively). An amniotic fluid interleukin\u20106 cutoff value of \u226515.5\u00a0ng\/mL was associated with a significant risk of FIRS (adjusted odds ratio: 27.9; 95% confidence interval: 6.3\u2013123.0; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of this study show that amniotic interleukin 6 alone can be used to diagnose FIRS prenatally. While there is a need for validation, it may be possible to treat IAI while preventing damage to the central nervous and respiratory systems in the uterus by keeping the amniotic fluid interleukin\u20106 below the cutoff value.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15630","type":"journal-article","created":{"date-parts":[[2023,3,4]],"date-time":"2023-03-04T08:38:34Z","timestamp":1677919114000},"page":"1498-1505","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Diagnostic accuracy of amniotic fluid interleukin\u20106 for fetal inflammatory response syndrome"],"prefix":"10.1111","volume":"49","author":[{"given":"Kana","family":"Ohkuma","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology National Hospital Organization, Saga National Hospital  Saga Japan"},{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Saga University  Saga 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