{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T20:12:46Z","timestamp":1773173566099,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>In this review, We compared clinical characteristics of pregnant women aged 50 and older with those aged 45\u201349. Pregnant women \u226545\u2009years are strongly associated with pregnancy\u2010related complications, such as cesarean section rate, gestational hypertension, gestational diabetes mellitus, and preterm birth. Although pregnant women \u226550\u2009years are considered more high\u2010risk, differences in pregnancy outcomes between those over 45 and 50\u2009years of age are unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our source strategy included using PubMed, the Cochrane Central Register of Controlled Trials, and Web of Science databases to include studies published between January 1, 2010 and September 30, 2022. The study population was pregnant women 50\u2009years and older; the control group was pregnant women aged 45\u201349\u2009years. Primary outcomes were cesarean section, gestational hypertension, gestational diabetes mellitus, and preterm birth. The secondary outcomes were small\u2010for\u2010gestational age, 5\u2010min Apgar score\u2009&lt;\u20097, neonatal intensive care unit admission (as neonatal outcomes), nulliparity, assisted reproductive technology (ART), and multifetal pregnancy (as maternal backgrounds).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of cesarean section, gestational hypertension, and preterm delivery was significantly higher in those 50\u2009years and older; however, significant differences disappeared when pooled analyses were limited to singleton pregnancies. ART was significantly more likely to be used for conception of pregnant women \u226550\u2009years. Infants of women \u226550\u2009years were more likely to be admitted to NICUs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The differences in outcomes between the two groups are obviously influenced by multiple pregnancies, therefore, reproductive medicine specialists should aim for singleton pregnancies in ART.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15662","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T05:18:38Z","timestamp":1682659118000},"page":"1689-1699","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Obstetrical outcomes of pregnant women 50\u2009years and older compared to those aged 45\u201349\u2009years: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"49","author":[{"given":"Shunya","family":"Sugai","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Niigata University Medical and Dental Hospital  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Sekizuka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Niigata University Medical and Dental Hospital  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazufumi","family":"Haino","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Niigata University Medical and Dental Hospital  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Nonaka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Niigata University Medical and Dental Hospital  Niigata Japan"},{"name":"Department of Obstetrics and Gynecology Nagaoka Red Cross Hospital  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0751-6395","authenticated-orcid":false,"given":"Masayuki","family":"Sekine","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Niigata University Medical and Dental Hospital  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2254-3378","authenticated-orcid":false,"given":"Kosuke","family":"Yoshihara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Niigata University Medical and Dental Hospital  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2050-5543","authenticated-orcid":false,"given":"Koji","family":"Nishijima","sequence":"additional","affiliation":[{"name":"Center for Perinatal, Maternal and Neonatal Medicine Niigata University Medical and Dental Hospital  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,27]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"835","article-title":"Successful delivery after age 50: a report of two cases as a result of oocyte donation","volume":"81","author":"Check JH","year":"1993","journal-title":"Obstet Gynecol"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-010-9418-3"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.07.022"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.09.103"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.09.037"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.midw.2010.07.006"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12659"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096237"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-017-1540-0"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-019-2415-3"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-019-2239-1"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.14064"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.07.039"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2023.100885"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2018.03.001"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14257"},{"key":"e_1_2_10_18_1","first-page":"15","article-title":"Is the risk of preeclampsia higher in donor oocyte pregnancies? A systematic review and meta\u2010analysis","volume":"22","author":"Schwarze JE","year":"2018","journal-title":"JBRA Assist Reprod"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-019-01552-4"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2021.02.003"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2012.09.016"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.2307\/2533446"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.02.031"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-015-1914-8"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2015.204"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2015.1051955"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.09.021"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2017.07.029"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1700859"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-58583-6"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004397"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000017"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000818"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k4372"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)56568-6"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.03.004"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186287"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12494"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-015-0557-3"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss6411a1"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.07.002"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss7104a1"},{"key":"e_1_2_10_43_1","first-page":"e1","article-title":"Application of a validated prediction model for in vitro fertilization: comparison of live birth rates and multiple birth rates with 1 embryo transferred over 2 cycles vs 2 embryos in 1 cycle","volume":"212","author":"Luke B","year":"2015","journal-title":"Am J Obstet Gynecol"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.15662","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T13:22:20Z","timestamp":1692278540000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.15662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,27]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1111\/jog.15662"],"URL":"https:\/\/doi.org\/10.1111\/jog.15662","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,27]]},"assertion":[{"value":"2023-03-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}