{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T07:36:02Z","timestamp":1783668962116,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,5,21]],"date-time":"2023-05-21T00:00:00Z","timestamp":1684627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Hyperemesis gravidarum (HG) is one of the most common serious diseases in early pregnancy. This study aimed to investigate the clinical significance of hemoglobin, albumin, lymphocyte, and platelet (HALP) score and systemic immune inflammation (SII) index in the presence and severity of HG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective case\u2013control study was conducted in a training and educational university hospital between January 2019 and July 2022. A total of 521 pregnant women, of whom 360 were diagnosed with HG at 6\u201314\u2009weeks of gestation and 161 were low\u2010risk pregnancies, were included in the study. Patients' demographic characteristics and laboratory parameters were recorded. Patients with HG were divided into three categories: mild (<jats:italic>n<\/jats:italic>\u2009=\u2009160), moderate (<jats:italic>n<\/jats:italic>\u2009=\u2009116), and severe (<jats:italic>n<\/jats:italic>\u2009=\u200984), according to disease severity. The modified PUQE scoring was used to determine the severity of HG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the patients was 27.6 (16\u201340) years. We divided the pregnant women into the control group and HG group. The HALP score was significantly lower in the HG group (average, 2.8\u2009\u00b1\u20091.3), whereas the SII index was found to be significantly higher (average, 895.8\u2009\u00b1\u2009458.1). A negative correlation was found between the increase in the severity of HG and HALP score. The HALP score was the lower in severe HG (mean, 2.16\u2009\u00b1\u20090.81) and was significantly different from other HG categories (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Moreover, a positive correlation was noted between increased HG severity and SII index levels. The SII index was higher in the severe HG group and was significantly different from the others (1001.2\u2009\u00b1\u2009437.2) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The HALP score and SII index can be useful, cost\u2010effective, and easily accessible objective biomarkers to predict the presence and severity of HG.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15666","type":"journal-article","created":{"date-parts":[[2023,5,21]],"date-time":"2023-05-21T23:24:45Z","timestamp":1684711485000},"page":"1729-1735","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The predictive value of HALP score and systemic immune inflammation (SII) index in hyperemesis gravidarum"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1735-6997","authenticated-orcid":false,"given":"Feyza","family":"Bayram","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Bursa Yuksek Ihtisas Educational and Research Hospital  Bursa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7888-7583","authenticated-orcid":false,"given":"Gulten","family":"Ozgen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Bursa Yuksek Ihtisas Educational and Research Hospital  Bursa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00fcleyman Serkan","family":"Karas\u0131n","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Bursa Yuksek Ihtisas Educational and Research Hospital  Bursa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0070-2646","authenticated-orcid":false,"given":"Levent","family":"Ozgen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Uludag University  Bursa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1003896"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.10205"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(02)02024-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmi021"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000195059.82029.74"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.02.012"},{"key":"e_1_2_8_8_1","first-page":"138","article-title":"Vaspin and Creactive protein levels in hyperemesis gravidarum","volume":"17","author":"Engin Ustun Y","year":"2013","journal-title":"Eur Rev Med 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