{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:40:18Z","timestamp":1782387618751,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T00:00:00Z","timestamp":1684972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Condylomata acuminata, or genital warts (GW), are exceedingly prevalent, with human papilloma virus infection accounting for 90% of cases. It can be treated in a variety of methods, but the high recurrence rate and cervical scars make it difficult to choose the best treatment option. Hence, the study aims to find the effect of laser combined with 5\u2010aminolevulinic acid (ALA) photodynamic therapy for condyloma acuminata in the vulva, vagina, and cervix.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 106 female patients with GW of the vulva, vagina, and cervical condyloma acuminata were treated in the Dermatology Department of Subei People's Hospital in Yangzhou from May 2020 to July 2021. All these patients were treated with laser combined with 5\u2010ALA photodynamic therapy to observe the therapeutic effect.<\/jats:p><\/jats:sec>Results<\/jats:title>About 84.9% of patients responded to the first session of ALA\u2010photodynamic treatment. Five patients relapsed in the 2nd week, two patients relapsed in the 4th week, one relapsed in the 8th week, one relapsed in the 12th week, and the relapsed patients were given 1\u20133 times of photodynamic therapy again, and no recurrence was seen in the 24th week. After four courses of treatment in 106 patients, the wart clearance rate was 100%.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Laser combined with 5\u2010ALA photodynamic therapy for female vulva, vagina, and cervix condyloma acuminata has a reliable curative effect, low recurrence rate, few adverse reactions, and less pain. It is worth promoting in female vulva, vagina, and cervical condyloma acuminata.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15679","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T02:50:30Z","timestamp":1685069430000},"page":"2010-2014","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical observation of laser combined with 5\u2010aminolevulinic acid photodynamic therapy for female vulva condyloma acuminatum"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6213-3947","authenticated-orcid":false,"given":"Zian","family":"Zhao","sequence":"first","affiliation":[{"name":"School of Clinical medicine Yangzhou University Yangzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Abdullahi","family":"jama","sequence":"additional","affiliation":[{"name":"School of Clinical medicine Yangzhou University Yangzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Clinical medicine Yangzhou University Yangzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Clinical medicine Yangzhou University Yangzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/342109"},{"key":"e_1_2_7_3_1","volume-title":"Condyloma acuminata","author":"Pennycook KB"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-014-1922-y"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.201756411"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2007.06659.x"},{"issue":"12","key":"e_1_2_7_7_1","first-page":"2335","article-title":"Management of genital warts","volume":"70","author":"Kodner C","year":"2004","journal-title":"Am Fam Physician"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.039677-0"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07648.x"},{"issue":"16","key":"e_1_2_7_10_1","first-page":"2925","article-title":"Photodynamic therapy of condyloma acuminata in pregnant women","volume":"125","author":"Yang YG","year":"2012","journal-title":"Chin Med J"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01125.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12043"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1078\/1615-1615-00028"},{"key":"e_1_2_7_14_1","volume-title":"SPSS statistics version 22: a practical guide","author":"Allen P","year":"2014"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2016-053035"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-019-05242-5"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2018.06.022"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10089.x"},{"issue":"4","key":"e_1_2_7_19_1","first-page":"961","article-title":"Therapeutic effects of topical 5\u2010aminolevulinic acid photodynamic therapy","volume":"32","author":"Hu Y\u2010E","year":"2016","journal-title":"Pak J Med Sci"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000346330"},{"issue":"4","key":"e_1_2_7_21_1","first-page":"187","article-title":"CO2 laser therapy versus cryotherapy in treatment of genital warts; 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