{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T06:12:56Z","timestamp":1778998376913,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T00:00:00Z","timestamp":1686355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We examined the heart failure biomarker mid\u2010regional pro\u2010atrial natriuretic peptide during the first trimester of pregnancy in relation to early\u2010onset preeclampsia &lt;34\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This case\u2013control study included 34 women with singleton pregnancies with a preeclampsia diagnosis and delivery before 34\u2009weeks of gestation who had attended the routine first\u2010trimester ultrasound scan at 11\u201313+6 weeks of gestation between August 2010 and October 2015 at the Copenhagen University Hospital Rigshospitalet, Denmark, and 91 uncomplicated singleton pregnancies matched by time of the routine first\u2010trimester blood sampling at 8\u201313+6\u2009weeks.<\/jats:p><jats:p>Descriptive statistical analyses were performed for maternal characteristics and obstetric and medical history for the case versus the control group. Concentrations of mid\u2010regional pro\u2010atrial natriuretic peptide, placental growth factor, soluble fms\u2010like tyrosine kinase\u20101, and pregnancy\u2010associated plasma protein A between early\u2010onset preeclampsia cases and the control group were compared using Students <jats:italic>t<\/jats:italic>\u2010test and the Mann\u2013Whitney <jats:italic>U<\/jats:italic> test. Biochemical marker concentrations were converted into multiples of the expected median values after adjustment for gestational age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mid\u2010regional pro\u2010atrial natriuretic peptide levels were not significantly different between early\u2010onset preeclampsia cases and the control group in the first trimester of pregnancy. As expected, both placental growth factor and pregnancy\u2010associated plasma protein A levels were significantly lower in early\u2010onset preeclampsia, whereas soluble fms\u2010like tyrosine kinase\u20101 levels were not statistically significantly different.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The maternal first\u2010trimester concentration of mid\u2010regional pro\u2010atrial natriuretic peptide, a peptide with multiple biological functions including a relation to cardiovascular disease, was not significantly different in women with early\u2010onset preeclampsia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15700","type":"journal-article","created":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T07:39:28Z","timestamp":1686382768000},"page":"2040-2047","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lack of an association between first\u2010trimester concentration of mid\u2010regional pro\u2010atrial natriuretic peptide and risk of early\u2010onset preeclampsia &lt;34\u2009weeks' gestation"],"prefix":"10.1111","volume":"49","author":[{"given":"Signe Milling","family":"Mortensen","sequence":"first","affiliation":[{"name":"Center of Fetal Medicine and Pregnancy, Department of Obstetrics Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8337-5101","authenticated-orcid":false,"given":"Charlotte Kvist","family":"Ekelund","sequence":"additional","affiliation":[{"name":"Center of Fetal Medicine and Pregnancy, Department of Obstetrics Copenhagen University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berit Woetmann","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of 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