{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:48:22Z","timestamp":1788997702546,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T00:00:00Z","timestamp":1687564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We investigated the frequency of early recurrence of vaginal intraepithelial neoplasia grade 2\/3 (VaIN 2\/3) (within 2\u2009years) after hysterectomy for cervical intraepithelial neoplasia grade 3 (CIN3). The characteristics of the clinicopathological factors common to them were explored including different surgical methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>As a retrospective observational study, a total of 647 CIN3 patients were divided into a conization and hysterectomy group (C group, <jats:italic>n<\/jats:italic>\u2009=\u2009492; H group, <jats:italic>n<\/jats:italic>\u2009=\u2009155), and HSIL (CIN2\/3 or VaIN2\/3) recurrence within 2\u2009years after surgery was evaluated. A stratified analyses was performed. Surgical methods were divided into trans\u2010abdominal, trans\u2010vaginal, and laparoscopic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The recurrence of VaIN3 was detected in four cases (2.6%) in the H group, which was similar to that of CIN2\/3 in the C group, 12 out of 491 patients (2.4%). The patients who developed VaIN3 were significantly older than those who did not (median, VaIN3: 71.0; VaIN1 and less: 48.0; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). All VaIN3 cases were detected within 5\u2009months, although majority of cases were negative in the margin (3\/4 cases; margin negative). The method of hysterectomy was not related to the VaIN3 recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For CIN3 patients for whom hysterectomy is the main treatment, VaIN3 can develop in 2.6% within very shortly after operation even if surgical margin was negative. The elder the age, the higher the risk of early recurrence could be. Laparoscopic surgery is considered to be acceptable methods of hysterectomy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15723","type":"journal-article","created":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T01:46:11Z","timestamp":1687657571000},"page":"2361-2369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["High\u2010grade vaginal intraepithelial neoplasia after hysterectomy for high\u2010grade cervical intraepithelial neoplasia: Is hysterectomy a \u201cdefinitive\u201d treatment compared to conization?"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6261-2219","authenticated-orcid":false,"given":"Miyu","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics, Graduate School of Medicine Kyoto University  Kyoto 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