{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:07:51Z","timestamp":1780445271085,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T00:00:00Z","timestamp":1687737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the influence of insemination methods on clinical outcomes by assessing preimplantation genetic testing for aneuploidy (PGT\u2010A) outcomes in embryos obtained using in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) in sibling mature oocytes from high\u2010risk patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study involved 108 couples with nonmale or mild male factor infertility who underwent split insemination cycles from January 2018 to December 2021. PGT\u2010A was performed using trophectoderm biopsy, array comparative genome hybridization, or next\u2010generation sequencing with 24\u2010chromosome screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mature oocytes were divided into IVF (<jats:italic>n<\/jats:italic>\u2009=\u2009660) and ICSI (<jats:italic>n<\/jats:italic>\u2009=\u20091028) groups. The normal fertilization incidence was similar between the groups (81.1% vs. 84.6%). The total number of blastocysts biopsied was significantly higher in the IVF group than in the ICSI group (59.3% vs. 52.6%; <jats:italic>p<\/jats:italic>\u2009=\u20090.018). However, euploidy (34.4% vs. 31.9%) and aneuploidy (63.4% vs. 66.2%) rates per biopsy and clinical pregnancy rates (60.0% vs. 58.8%) were similar between the groups. Implantation (45.6% vs. 50.8%) and live birth or ongoing pregnancy (52.0% vs 58.8%) rates were slightly higher in the ICSI group than in the IVF group and miscarriage rate per transfer was slightly higher in the IVF group than in the ICSI group (12.0% vs 5.9%); however no significant difference was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>IVF and ICSI using sibling mature oocytes had similar clinical outcomes, and euploidy and aneuploidy rates in couples with nonmale and mild male factor infertility. These results suggest that IVF is a useful option, along with ICSI, as an insemination method in PGT\u2010A cycles, especially in high\u2010risk patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15731","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T01:09:35Z","timestamp":1687828175000},"page":"2343-2350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of clinical and preimplantation genetic testing for aneuploidy outcomes between in vitro fertilization and intracytoplasmic sperm injection in sibling mature oocytes from high\u2010risk patients: A retrospective study"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5285-5076","authenticated-orcid":false,"given":"Jun\u2010Woo","family":"Kim","sequence":"first","affiliation":[{"name":"In Vitro Fertilization Center Maria S Fertility Hospital  Seoul Republic of Korea"},{"name":"Department of Applied Animal Science, College of Animal Life Sciences Kangwon National University  Chuncheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So\u2010Young","family":"Lee","sequence":"additional","affiliation":[{"name":"In Vitro Fertilization Center Maria S Fertility Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Young","family":"Hur","sequence":"additional","affiliation":[{"name":"In Vitro Fertilization Center Maria S Fertility Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Ho","family":"Lim","sequence":"additional","affiliation":[{"name":"In Vitro Fertilization Center Maria S Fertility Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choon\u2010Keun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Applied Animal 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