{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T17:07:03Z","timestamp":1778260023919,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The incidence of chromosomal polymorphisms (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>) is increased in infertile couples, but its impact on reproduction is uncertain, especially undergoing assisted reproductive technology treatment. The purpose of the present study was to investigate the effect of<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>on the outcomes of in vitro fertilization\/intracytoplasmic sperm injection\u2010embryo transfer (<jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ICSI\u2010ET<\/jats:styled-content>) treatment<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1331 infertile couples undergoing IVF\/ICSI treatment were involved in this retrospective case\u2013control study. The participants were divided into 4 groups according to CP variations: (i) normal chromosomes (NC) group; (ii) CP group; (iii) both chromosomal polymorphisms (BCP) group; and (iv) double chromosomal polymorphisms (DCP) group. The CP group was further divided into five subgroups: qh+, D\/G, inv(9), Yqh+\u2009and Yqh\u2212. The outcomes of IVF\/ICSI\u2010ET treatment were compared among the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no differences observed between the eight groups in terms of number of oocytes retrieved, MII rate, fertilization rate, cleaved embryo rate, and quality embryo rate for both females and males (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). In both male and female, some of the CP subgroups experienced more oocyte retrieval operations and more embryo transfer operations to achieve pregnancy than the NC groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The rates of live births were significantly lower in some of the CP subgroups compared to the NC group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, the pregnancy outcomes of ET were affected by<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>. It was speculated that this may be associated with the effect of chromosome polymorphism on embryo quality, although this could not be observed or determined by morphological evaluation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15732","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T04:35:11Z","timestamp":1689136511000},"page":"2351-2360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of chromosomal polymorphisms on the outcome of in vitro fertilization and embryo transfer"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1475-3321","authenticated-orcid":false,"given":"Lixia","family":"Liang","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine Childrens Hospital of Shanxi and Women Health Center of Shanxi Taiyuan 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