{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:49:47Z","timestamp":1780580987877,"version":"3.54.1"},"reference-count":9,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T00:00:00Z","timestamp":1691020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.pericles-gcp.literatumonline.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Chronic abruption\u2010oligohydramnios sequence (CAOS), which is characterized by vaginal bleeding and oligohydramnios, adversely affects the lungs of fetuses due to bloody amniotic fluid and oligohydramnios. The criteria for termination of pregnancy remain controversial. This study aimed to examine respiratory function in infants within 3\u2009years after birth and risk factors for respiratory prognosis, and to clarify the management of CAOS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study is a case series of patients with CAOS managed at our institution between 2010 and 2020. The clinical data of the patients and their infants within 3\u2009years after birth were reviewed. The amniotic fluid volume was measured using the maximum vertical pocket (MVP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six of 17 neonates (35.3%) used inhaled nitric oxide (iNO) to improve oxygenation. Women with longer periods of MVP &lt;1\u2009cm delivered more neonates using iNO; however, periods of MVP &lt;2\u2009cm were not associated with iNO use. Almost half of the infants required home oxygen therapy when discharged, regardless of amniotic fluid volume. At 18\u2009months corrected age, only one child needed respiratory support, and the others discontinued. Two neonates, both born at 23\u2009weeks of gestational age, died within 1\u2009month after birth because of extremely preterm birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The amniotic fluid volume could predict the use of iNO in neonates, but it did not affect the child's respiratory function after the newborn period. Almost all children born to women with CAOS can improve their respiratory function as they grow up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15755","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T09:28:27Z","timestamp":1691054907000},"page":"2649-2655","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The prognosis of neonatal respiratory status within three\u2009years after birth in chronic abruption\u2010oligohydramnios sequence"],"prefix":"10.1111","volume":"49","author":[{"given":"Shoko","family":"Nishikawa","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1540-0985","authenticated-orcid":false,"given":"Mana","family":"Taki","sequence":"additional","affiliation":[{"name":"Department of 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