{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:12:33Z","timestamp":1787015553284,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.pericles-gcp.literatumonline.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A 48\u2010year\u2010old woman underwent total abdominal hysterectomy and right salpingo\u2010oophorectomy and was initially diagnosed with a uterine leiomyoma and right ovarian cystadenoma. After 4\u2009years, multiple pulmonary metastases were identified, and treatment with gonadotropin\u2010releasing hormone agonists was started, but stopped later due to disease progression. The patient developed dyspnea and underwent right upper lobectomy. The histopathological findings were consistent with those of pulmonary metastases secondary to a uterine smooth muscle tumor of uncertain malignant potential. Slow disease progression after a poor response to adriamycin and hormone receptor positivity led to the start of letrozole. Letrozole induced spontaneous regression of the pulmonary metastases, and about 2\u2009years into the treatment, sustained response was achieved with minimal side effects. This may be the first case supporting the long\u2010term efficacy and safety of letrozole in the management of adriamycin\u2010resistant lung metastases of uterine smooth muscle tumors of uncertain malignant potential.<\/jats:p>","DOI":"10.1111\/jog.15777","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T02:34:45Z","timestamp":1692844485000},"page":"2771-2776","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010term effect of letrozole on metastatic uterine smooth muscle tumors of uncertain malignant potential: A case report"],"prefix":"10.1111","volume":"49","author":[{"given":"Padiachy","family":"Praben","sequence":"first","affiliation":[{"name":"Department of General Medicine Faculty of Medicine, Juntendo University  Tokyo 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