{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:36:25Z","timestamp":1747186585126,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T00:00:00Z","timestamp":1693958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22gk0110059h001"],"award-info":[{"award-number":["JP22gk0110059h001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Although perinatal thrombotic microangiopathy has become increasingly understood, the racial characteristics of patients with this condition remain unclear. Herein, we report the characteristics of patients with perinatal thrombotic microangiopathy at a single institution in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective study over a 5\u2010year period from January 1, 2017, to December 31, 2021, using the electronic medical records of pregnant women who delivered at the perinatal center of our hospital. We extracted the data of those who developed perinatal thrombotic microangiopathy and evaluated their characteristics at the time of disease onset, final diagnosis, and maternal and fetal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 10\u2009224 deliveries that occurred during the 5\u2010year period, only seven patients (0.06%) had perinatal thrombotic microangiopathy. The median pre\u2010pregnant body mass index was 18.65\u2009kg\/m<jats:sup>2<\/jats:sup> (minimum 17.3\u2009kg\/m<jats:sup>2<\/jats:sup>, maximum 20.7\u2009kg\/m<jats:sup>2<\/jats:sup>). More than half of the patients were conceived by in\u2010vitro fertilization, and 42% these had twin deliveries. Four patients had a history of rheumatic disease. The other three patients without underlying diseases developed thrombotic microangiopathy with HELLP syndrome, and one patient transitioned to atypical hemolytic uremic syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on low body mass index and in\u2010vitro fertilization, which are characteristic of Japanese women, medical complications and twin pregnancies may be a risk for thrombotic microangiopathy. Additionally, depending on the cause of thrombotic microangiopathy, its timing and onset differed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.15790","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T08:31:24Z","timestamp":1693989084000},"page":"2804-2810","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical features of women with thrombotic microangiopathy in pregnancy: A case series from a single Japanese tertiary perinatal care center"],"prefix":"10.1111","volume":"49","author":[{"given":"Kanako","family":"Nagaoka","sequence":"first","affiliation":[{"name":"Department of Maternal Medicine, Center of Maternal\u2010Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3411-5896","authenticated-orcid":false,"given":"Kayoko","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Maternal Medicine, Center of Maternal\u2010Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiko","family":"Miyagawa","sequence":"additional","affiliation":[{"name":"Department of Maternal Medicine, Center of Maternal\u2010Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sawako","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Maternal Medicine, Center of Maternal\u2010Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chie","family":"Kohno","sequence":"additional","affiliation":[{"name":"Department of Maternal Medicine, Center of Maternal\u2010Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotoyi","family":"Tsurane","sequence":"additional","affiliation":[{"name":"Department of Maternal Medicine, Center of Maternal\u2010Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asako","family":"Mito","sequence":"additional","affiliation":[{"name":"Department of Maternal Medicine, Center of Maternal\u2010Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1748-1635","authenticated-orcid":false,"given":"Nobuaki","family":"Ozawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Center of Maternal\u2010Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhiko","family":"Sago","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Center of Maternal\u2010Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Arata","sequence":"additional","affiliation":[{"name":"Department of Maternal Medicine, Center of Maternal\u2010Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuko","family":"Murashima","sequence":"additional","affiliation":[{"name":"Department of Maternal Medicine, Center of Maternal\u2010Fetal, Neonatal and Reproductive Medicine National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30062-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2018.02.007"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2021000290"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(17)30069-5"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-014-0416-x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.13044"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.je.2016.09.013"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.90.184"},{"key":"e_1_2_9_10_1","unstructured":"Ministry of Health LaW.Summary of vital statistics (fixed number). 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